ENSMUSG00000015120


Mus musculus

Features
Gene ID: ENSMUSG00000015120
  
Biological name :Ube2i
  
Synonyms : P63280 / Ube2i / ubiquitin-conjugating enzyme E2I
  
Possible biological names infered from orthology : P63279
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25261916
Gene end: 25274622
  
Corresponding Affymetrix probe sets: 10478012 (MoGene1.0st)   10598636 (MoGene1.0st)   1422712_a_at (Mouse Genome 430 2.0 Array)   1422713_a_at (Mouse Genome 430 2.0 Array)   1422714_at (Mouse Genome 430 2.0 Array)   1425478_x_at (Mouse Genome 430 2.0 Array)   1429545_at (Mouse Genome 430 2.0 Array)   1436457_at (Mouse Genome 430 2.0 Array)   1453189_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134546
Ensembl peptide - ENSMUSP00000055714
Ensembl peptide - ENSMUSP00000133311
Ensembl peptide - ENSMUSP00000133338
Ensembl peptide - ENSMUSP00000133590
Ensembl peptide - ENSMUSP00000134161
Ensembl peptide - ENSMUSP00000134169
Ensembl peptide - ENSMUSP00000134261
Ensembl peptide - ENSMUSP00000134350
Ensembl peptide - ENSMUSP00000134450
Ensembl peptide - ENSMUSP00000134491
Ensembl peptide - ENSMUSP00000134540
NCBI entrez gene - 22196     See in Manteia.
MGI - MGI:107365
RefSeq - XM_006524049
RefSeq - NM_001177609
RefSeq - NM_001177610
RefSeq - NM_011665
RefSeq - XM_006524048
RefSeq Peptide - NP_001171080
RefSeq Peptide - NP_001171081
RefSeq Peptide - NP_001344623
RefSeq Peptide - NP_035795
swissprot - G3UWL6
swissprot - Q8CFZ0
swissprot - P63280
swissprot - G3UWJ1
swissprot - G3UYP0
swissprot - G3UZL6
Ensembl - ENSMUSG00000015120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9DDJ0ENSDARG00000052649Danio rerio
 Q9W6H5ENSDARG00000007438Danio rerio
 UBE2IENSGALG00000006428Gallus gallus
 UBE2IENSG00000103275Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site
 IPR027230  SUMO-conjugating enzyme Ubc9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1903755 positive regulation of SUMO transferase activity ISO
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016605 PML body ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:1990234 transferase complex ISO
 cellular_componentGO:1990356 sumoylated E2 ligase complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0043398 HLH domain binding IPI
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0044388 small protein activating enzyme binding ISO
 molecular_functionGO:0061656 SUMO conjugating enzyme activity ISO
 molecular_functionGO:0071535 RING-like zinc finger domain binding ISO


Pathways (from Reactome)
Pathway description
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction
 ENSMUSG00000003226 Q9ERU9 / Ranbp2 / E3 SUMO-protein ligase RanBP2 / RGPD3* / RGPD2* / RGPD1* / RGPD8* / RGPD6* / RGPD5* / RGPD4* / A6NKT7* / O14715* / P0DJD0* / P0DJD1* / P49792* / Q7Z3J3* / Q99666* / RAN b...  / complex / reaction
 ENSMUSG00000002108 Nr1h3 / Q9Z0Y9 / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA. / Q13133* / nuclear receptor subfamily 1 group H member 3*  / reaction
 ENSMUSG00000021144 Mta1 / Q8K4B0 / Mus musculus metastasis associated 1 (Mta1), transcript variant 2, mRNA. / Q13330* / metastasis associated 1*  / reaction
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSMUSG00000004099 Dnmt1 / P13864 / DNA (cytosine-5)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / reaction
 ENSMUSG00000026313 Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*  / reaction
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / reaction
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / reaction
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction
 ENSMUSG00000020738 Sumo2 / P61957 / small ubiquitin-like modifier 2  / complex
 ENSMUSG00000019777 Hdac2 / histone deacetylase 2 / Q92769*  / reaction
 ENSMUSG00000017485 Top2b / Q64511 / DNA topoisomerase 2-beta / Q02880* / DNA topoisomerase II beta*  / reaction
 ENSMUSG00000021779 Thrb / P37242 / Thyroid hormone receptor beta / P10828*  / reaction
 ENSMUSG00000026398 Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*  / reaction
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction
 ENSMUSG00000026751 Nr5a1 / P33242 / Steroidogenic factor 1 / Q13285* / nuclear receptor subfamily 5 group A member 1*  / reaction
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / reaction
 ENSMUSG00000038331 Satb2 / Q8VI24 / special AT-rich sequence binding protein 2 / Q9UPW6* / SATB homeobox 2*  / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction
 ENSMUSG00000035158 Mitf / Q08874 / melanogenesis associated transcription factor / O75030*  / reaction
 ENSMUSG00000032238 Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*  / reaction
 ENSMUSG00000028640 Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*  / reaction
 ENSMUSG00000029167 O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*  / reaction
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / reaction
 ENSMUSG00000028964 Park7 / Q99LX0 / Protein/nucleic acid deglycase DJ-1 / Q99497* / Parkinsonism associated deglycase*  / reaction
 ENSMUSG00000031347 Cetn2 / Q9R1K9 / Centrin-2 / P41208*  / reaction
 ENSMUSG00000036822 Q80Z37 / Topors / E3 ubiquitin-protein ligase Topors / Q9NS56* / TOP1 binding arginine/serine rich protein*  / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction
 ENSMUSG00000030094 Xpc / P51612 / xeroderma pigmentosum, complementation group C / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction
 ENSMUSG00000042557 Sin3a / Q60520 / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA. / Q96ST3* / SIN3 transcription regulator family member A*  / reaction
 ENSMUSG00000026222 Sp100 / O35892 / nuclear antigen Sp100 / Q9H930* / P23497* / SP140L* / SP100 nuclear antigen* / SP140 nuclear body protein like*  / reaction
 ENSMUSG00000055065 Ddx17 / Q501J6 / Probable ATP-dependent RNA helicase DDX17 / Q92841* / DEAD-box helicase 17*  / reaction
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / complex / reaction
 ENSMUSG00000022809 Nr1i2 / O54915 / Nuclear receptor subfamily 1 group I member 2 / O75469*  / reaction
 ENSMUSG00000026020 Nop58 / Q6DFW4 / Nucleolar protein 58 / Q9Y2X3* / NOP58 ribonucleoprotein*  / reaction
 ENSMUSG00000030166 Rad52 / P43352 / RAD52 homolog, DNA repair protein / P43351*  / reaction
 ENSMUSG00000043099 Hic1 / HIC ZBTB transcriptional repressor 1 / Q14526*  / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000020914 Top2a / Q01320 / DNA topoisomerase 2-alpha / P11388* / DNA topoisomerase II alpha*  / reaction
 ENSMUSG00000037373 Ctbp1 / O88712 / C-terminal-binding protein 1 / Q13363*  / reaction
 ENSMUSG00000024561 Mbd1 / Mus musculus methyl-CpG binding domain protein 1 (Mbd1), transcript variant 4, mRNA. / Q9UIS9* / methyl-CpG binding domain protein 1*  / reaction
 ENSMUSG00000002307 Daxx / Mus musculus Fas death domain-associated protein (Daxx), transcript variant 3, mRNA. / Q9UER7* / death domain associated protein*  / reaction
 ENSMUSG00000005897 Nr2c1 / Q505F1 / Nuclear receptor subfamily 2 group C member 1 / P13056*  / reaction
 ENSMUSG00000060601 Nr1h2 / Q60644 / Oxysterols receptor LXR-beta / P55055* / nuclear receptor subfamily 1 group H member 2*  / reaction
 ENSMUSG00000034674 Tdg / P56581 / Mus musculus thymine DNA glycosylase (Tdg), transcript variant 3, mRNA. / Q13569* / thymine DNA glycosylase*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000070544 Top1 / Q04750 / DNA topoisomerase 1 / P11387* / DNA topoisomerase I*  / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction
 ENSMUSG00000047638 Nr1h4 / Q60641 / Bile acid receptor / Q96RI1* / nuclear receptor subfamily 1 group H member 4*  / reaction
 ENSMUSG00000048490 Nrip1 / Q8CBD1 / Mus musculus nuclear receptor interacting protein 1 (Nrip1), transcript variant 2, mRNA. / P48552* / nuclear receptor interacting protein 1*  / reaction
 ENSMUSG00000058756 Thra / P63058 / Thyroid hormone receptor alpha / P10827*  / reaction
 ENSMUSG00000027109 Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*  / reaction
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / reaction
 ENSMUSG00000027478 Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*  / reaction
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / reaction
 ENSMUSG00000050397 Foxl2 / O88470 / Forkhead box protein L2 / P58012* / forkhead box L2*  / reaction
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction
 ENSMUSG00000022391 P46061 / Rangap1 / Ran GTPase-activating protein 1 / P46060*  / complex
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / reaction
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction
 ENSMUSG00000029478 Ncor2 / Q9WU42 / Nuclear receptor corepressor 2 / Q9Y618*  / reaction
 ENSMUSG00000022383 Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*  / reaction
 ENSMUSG00000031870 Pgr / Q00175 / Progesterone receptor / P06401*  / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / reaction
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / reaction
 ENSMUSG00000071054 Safb / D3YXK2 / Scaffold attachment factor B1 / Q15424* / scaffold attachment factor B*  / reaction
 ENSMUSG00000020647 Ncoa1 / P70365 / Nuclear receptor coactivator 1 / Q15788*  / reaction
 ENSMUSG00000052833 Sae1 / Q9R1T2 / SUMO-activating enzyme subunit 1 SUMO-activating enzyme subunit 1, N-terminally processed / Q9UBE0* / SUMO1 activating enzyme subunit 1*  / reaction
 ENSMUSG00000036986 Pml / Q60953 / Protein PML / P29590* / promyelocytic leukemia*  / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / reaction
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / reaction
 ENSMUSG00000025225 Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*  / reaction
 ENSMUSG00000063049 Ing2 / Q9ESK4 / Inhibitor of growth protein 2 / Q9H160* / inhibitor of growth family member 2*  / reaction
 ENSMUSG00000009575 Cbx5 / Q61686 / Mus musculus chromobox 5 (Cbx5), transcript variant 4, mRNA. / P45973* / chromobox 5*  / reaction
 ENSMUSG00000052997 Uba2 / Q9Z1F9 / ubiquitin-like modifier activating enzyme 2 / Q9UBT2*  / reaction
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / reaction
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction
 ENSMUSG00000042292 Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*  / reaction
 ENSMUSG00000060373 Hnrnpc / Q9Z204 / Heteroous nuclear ribonucleoproteins C1/C2 / P07910* / heterogeneous nuclear ribonucleoprotein C (C1/C2)*  / reaction
 ENSMUSG00000061436 Hipk2 / Q9QZR5 / homeodomain interacting protein kinase 2 / Q9H2X6*  / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction
 ENSMUSG00000023927 Satb1 / Q60611 / Mus musculus special AT-rich sequence binding protein 1 (Satb1), transcript variant 5, mRNA. / Q01826* / SATB homeobox 1*  / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction
 ENSMUSG00000094870 Q8K3J5 / Zfp131 / zinc finger protein 131 / P52739* / ZNF131*  / reaction






 

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