ENSMUSG00000049932


Mus musculus

Features
Gene ID: ENSMUSG00000049932
  
Biological name :H2afx
  
Synonyms : H2afx / Histone H2AX / P27661
  
Possible biological names infered from orthology : H2A histone family member X / P16104
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 44334694
Gene end: 44336077
  
Corresponding Affymetrix probe sets: 10403955 (MoGene1.0st)   10404026 (MoGene1.0st)   10404045 (MoGene1.0st)   10408072 (MoGene1.0st)   10408085 (MoGene1.0st)   10408094 (MoGene1.0st)   10408111 (MoGene1.0st)   10409220 (MoGene1.0st)   10500324 (MoGene1.0st)   10584710 (MoGene1.0st)   1416746_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051432
NCBI entrez gene - 15270     See in Manteia.
MGI - MGI:102688
RefSeq - NM_010436
RefSeq Peptide - NP_034566
swissprot - P27661
Ensembl - ENSMUSG00000049932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR354435.3ENSDARG00000111536Danio rerio
 CR354435.4ENSDARG00000113707Danio rerio
 CU302436.3ENSDARG00000113800Danio rerio
 CU457819.1ENSDARG00000100279Danio rerio
 FP236812.2ENSDARG00000109926Danio rerio
 FP236812.4ENSDARG00000115875Danio rerio
 FP340257.1ENSDARG00000100024Danio rerio
 h2afxENSDARG00000029406Danio rerio
 h2afx1ENSDARG00000068995Danio rerio
 hist1h2a1ENSDARG00000109458Danio rerio
 hist1h2a10ENSDARG00000112840Danio rerio
 hist1h2a10ENSDARG00000105366Danio rerio
 hist1h2a11ENSDARG00000088686Danio rerio
 hist1h2a11ENSDARG00000100906Danio rerio
 hist1h2a11ENSDARG00000086552Danio rerio
 hist1h2a11ENSDARG00000098595Danio rerio
 hist1h2a11ENSDARG00000105444Danio rerio
 hist1h2a2ENSDARG00000070280Danio rerio
 hist1h2a2ENSDARG00000111648Danio rerio
 hist1h2a2ENSDARG00000109755Danio rerio
 hist1h2a2ENSDARG00000112593Danio rerio
 hist1h2a2ENSDARG00000110809Danio rerio
 hist1h2a4ENSDARG00000105314Danio rerio
 hist1h2a4ENSDARG00000099123Danio rerio
 hist1h2a4ENSDARG00000105400Danio rerio
 hist1h2a4ENSDARG00000103015Danio rerio
 hist1h2a4ENSDARG00000113399Danio rerio
 hist1h2a4ENSDARG00000051736Danio rerio
 hist1h2a5ENSDARG00000114133Danio rerio
 si:ch1073-153i20.5ENSDARG00000105478Danio rerio
 si:ch211-113a14.19ENSDARG00000113481Danio rerio
 ENSGALG00000026449Gallus gallus
 ENSGALG00000045705Gallus gallus
 H2AFXENSG00000188486Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64523 / Hist2h2ac / Histone H2A type 2-C ENSMUSG0000006885583
H2afj / Q8R1M2 / Histone H2A.J / Q9BTM1* / H2A histone family member J*ENSMUSG0000006003282
Q8CGP7 / Hist1h2ak / Histone H2A type 1-K ENSMUSG0000006302182
Q6GSS7 / Hist2h2aa2 / Histone H2A type 2-A ENSMUSG0000006395482
Q6GSS7 / Hist2h2aa1 / Histone H2A type 2-A / Q16777* / Q6FI13* / HIST2H2AC* / HIST2H2AA4* / histone cluster 2 H2A family member c* / histone cluster 2 H2A family member a4*ENSMUSG0000006422082
Q8BFU2 / Hist3h2a / Histone H2A type 3 / Q7L7L0* / histone cluster 3 H2A*ENSMUSG0000007885182
Q8CGP5 / Hist1h2af / Histone H2A type 1-F ENSMUSG0000006199181
Q64522 / Hist2h2ab / Histone H2A type 2-B / Q8IUE6* / histone cluster 2 H2A family member b*ENSMUSG0000006368981
Hist1h2aa / histone cluster 1, H2aa / Q96QV6* / histone cluster 1 H2A family member a*ENSMUSG0000006008176
H2afy / Q9QZQ8 / Core histone macro-H2A.1 / O75367* / H2A histone family member Y*ENSMUSG0000001593760
H2afy2 / Q8CCK0 / Core histone macro-H2A.2 / Q9P0M6* / H2A histone family member Y2*ENSMUSG0000002008659
H2afb1 / H2AFB3* / P0C5Z0* / H2AFB2* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000006744129
H2afb3 / H2AFB2* / P0C5Z0* / H2AFB1* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000008361629
H2afb2 / H2AFB3* / P0C5Z0* / H2AFB1* / P0C5Y9* / H2A histone family member B3* / H2A histone family member B1* / H2A histone family member B2*ENSMUSG0000008248227


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0090398 cellular senescence IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0001673 male germ cell nucleus IDA
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Bclaf1tm1Raz/Bclaf1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: H2afxtm1Nus/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: H2afxtm1Nus/H2afxtm1Nus,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: H2afxtm1Nus/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002627 teratoma "neoplasms composed of multiple tissue types; includes types not found in tissue in which lesion arises" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: H2afxtm1Fwa/H2afx+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2afxtm1Fwa/H2afxtm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: H2afxtm1Nus/H2afxtm1Nus,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0020321 increased vascular endothelial cell apoptosis "increase in the timing or the number of vascular endothelial cells undergoing programmed cell death" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / complex / reaction
 ENSMUSG00000002748 Baz1b / Q9Z277 / Tyrosine-protein kinase BAZ1B / Q9UIG0* / bromodomain adjacent to zinc finger domain 1B*  / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / complex / reaction
 ENSMUSG00000028886 Eya3 / P97480 / Eyes absent homolog 3 / Q99504* / EYA transcriptional coactivator and phosphatase 3*  / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / complex / reaction
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000031715 Q91ZW3 / Smarca5 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 / O60264*  / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / complex / reaction
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / complex / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / complex / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / complex
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / complex / reaction
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000037032 Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*  / complex / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / complex / reaction
 ENSMUSG00000060445 Sycp2 / Q9CUU3 / Synaptonemal complex protein 2 / Q9BX26*  / complex






 

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