ENSMUSG00000035234


Mus musculus

Features
Gene ID: ENSMUSG00000035234
  
Biological name :Abraxas1
  
Synonyms : Abraxas1 / BRCA1 A complex subunit / Q8BPZ8
  
Possible biological names infered from orthology : abraxas 1, BRCA1 A complex subunit / Q6UWZ7
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E4
Gene start: 100805192
Gene end: 100820965
  
Corresponding Affymetrix probe sets: 10531776 (MoGene1.0st)   1429774_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116476
Ensembl peptide - ENSMUSP00000143465
Ensembl peptide - ENSMUSP00000117012
Ensembl peptide - ENSMUSP00000047692
Ensembl peptide - ENSMUSP00000055895
Ensembl peptide - ENSMUSP00000114050
NCBI entrez gene - 70681     See in Manteia.
MGI - MGI:1917931
RefSeq - XM_006535217
RefSeq - XM_006535218
RefSeq - NM_172405
RefSeq Peptide - NP_765993
swissprot - Q8BPZ8
swissprot - D6RHB0
swissprot - D6RFD4
Ensembl - ENSMUSG00000035234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q1LVP6ENSDARG00000043339Danio rerio
 FAM175AENSGALG00000011210Gallus gallus
 Q6UWZ7ENSG00000163322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abraxas2 / BRISC complex subunit / Q15018* / abraxas 2, BRISC complex subunit*ENSMUSG0000003096529


Protein motifs (from Interpro)
Interpro ID Name
 IPR023238  FAM175 family
 IPR023239  FAM175 family, BRCA1-A complex, Abraxas 1 subunit
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010212 response to ionizing radiation ISO
 biological_processGO:0045739 positive regulation of DNA repair ISO
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0070531 BRCA1-A complex ISS
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding ISS


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / complex / reaction
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / complex / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / complex / reaction
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / complex / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / complex / reaction






 

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