ENSDARG00000043339


Danio rerio
dnaabraxas2arepairdamagefamfamilybrca-acomplexdouble-strandbreakresponsegcheckpointabraxassubunitchromatinorganizationcellularstimulusionizingradiationregulationsignaltransductioninvolvednucleuspolyubiquitinmodification-dependentproteinbinding

Features
Gene ID: ENSDARG00000043339
  
Biological name :abraxas2a
  
Synonyms : abraxas2a / abraxas 2a, BRISC complex subunit / Q1LVP6
  
Possible biological names infered from orthology : ABRAXAS1 / abraxas 1, BRCA1 A complex subunit / BRCA1 A complex subunit / Q6UWZ7 / Q8BPZ8
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 19319804
Gene end: 19329076
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000063620
swissprot - Q1LVP6
ZFIN ID - ZDB-GENE-041010-70
Ensembl - ENSDARG00000043339
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FAM175AENSGALG00000011210Gallus gallus
 Q6UWZ7ENSG00000163322Homo sapiens
 Q8BPZ8ENSMUSG00000035234Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
abraxas2b / abraxas 2b, BRISC complex subunit / Q15018* / ABRAXAS2* / BRISC complex subunit* / abraxas 2, BRISC complex subunit*ENSDARG0000009890729


Protein motifs (from Interpro)
Interpro ID Name
 IPR023238  FAM175 family
 IPR023239  FAM175 family, BRCA1-A complex, Abraxas 1 subunit


Gene Ontology (GO)
nitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationresponse to abiotic stimuluscell communicationcell cyclenitrogen componitrogen compound metabolic processresponse to stresponse to stresscellular metabcellular metabolic processprimary metaboprimary metabolic processorganic substaorganic substance metabolic processcellular respocellular response to stimuluscellular compocellular component organizationresponse to abresponse to abiotic stimuluscell communicacell communicationcell cyclecell cycle
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellcellorganelleorganelleprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010212 response to ionizing radiation ISS
 biological_processGO:0045739 positive regulation of DNA repair IBA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0070531 BRCA1-A complex ISS
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding ISS


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000026225 nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex / reaction
 ENSDARG00000028198 Q6PEH5 / ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000044949 rnf8 / ring finger protein 8, E3 ubiquitin protein ligase / Q8VC56* / O76064* / Gm28043* / ring finger protein 8* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSDARG00000073841 herc2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSDARG00000086764 mdc1 / mediator of DNA damage checkpoint 1 / Q14676*  / complex / reaction
 ENSDARG00000091187 BX649250.1 / UIMC1* / Q96RL1* / ubiquitin interaction motif containing 1*  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000042215 pias4b / protein inhibitor of activated STAT, 4b / PIAS4* / Q9JM05* / Q8N2W9* / protein inhibitor of activated STAT 4*  / complex / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000112483 rnf168 / ring finger protein 168 / Q8IYW5*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr