ENSMUSG00000028886


Mus musculus

Features
Gene ID: ENSMUSG00000028886
  
Biological name :Eya3
  
Synonyms : Eya3 / Eyes absent homolog 3 / P97480
  
Possible biological names infered from orthology : EYA transcriptional coactivator and phosphatase 3 / Q99504
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.3
Gene start: 132638987
Gene end: 132724765
  
Corresponding Affymetrix probe sets: 10508737 (MoGene1.0st)   1420933_a_at (Mouse Genome 430 2.0 Array)   1425989_a_at (Mouse Genome 430 2.0 Array)   1435443_at (Mouse Genome 430 2.0 Array)   1458961_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078157
Ensembl peptide - ENSMUSP00000123045
Ensembl peptide - ENSMUSP00000136812
Ensembl peptide - ENSMUSP00000020197
Ensembl peptide - ENSMUSP00000080425
NCBI entrez gene - 14050     See in Manteia.
MGI - MGI:109339
RefSeq - XM_006538540
RefSeq - NM_010166
RefSeq - NM_210071
RefSeq - NM_211357
RefSeq - XM_006538537
RefSeq - XM_006538538
RefSeq Peptide - NP_997596
RefSeq Peptide - NP_034296
RefSeq Peptide - NP_997592
swissprot - P97480
swissprot - Q6P4T3
swissprot - A2A953
Ensembl - ENSMUSG00000028886
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eya3ENSDARG00000036100Danio rerio
 EYA3ENSGALG00000000777Gallus gallus
 EYA3ENSG00000158161Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eya4 / Q9Z191 / Mus musculus EYA transcriptional coactivator and phosphatase 4 (Eya4), transcript variant 2, mRNA. / O95677* / EYA transcriptional coactivator and phosphatase 4*ENSMUSG0000001046144
Eya1 / P97767 / Eyes absent homolog 1 / Q99502* / EYA transcriptional coactivator and phosphatase 1*ENSMUSG0000002593243
Eya2 / O08575 / Eyes absent homolog 2 / O00167* / EYA transcriptional coactivator and phosphatase 2*ENSMUSG0000001789739


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR023214  HAD superfamily
 IPR028472  Eyes absent family
 IPR028479  Eyes absent homologue 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010212 response to ionizing radiation ISO
 biological_processGO:0016576 histone dephosphorylation ISO
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045739 positive regulation of DNA repair ISO
 biological_processGO:0048856 anatomical structure development IBA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 molecular_functionGO:0003682 chromatin binding IGI
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0005586 decreased tidal volume "less than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0010394 decreased QRS amplitude "reduction in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction






 

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