ENSDARG00000029406


Danio rerio

Features
Gene ID: ENSDARG00000029406
  
Biological name :h2afx
  
Synonyms : h2afx / H2A histone family, member X / Q7ZUY3
  
Possible biological names infered from orthology : Histone H2AX / P16104 / P27661
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 30534702
Gene end: 30535327
  
Corresponding Affymetrix probe sets: Dr.17357.1.A1_at (Zebrafish Array)   NM_201073_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000040327
NCBI entrez gene - 394048     See in Manteia.
RefSeq - NM_201073
RefSeq Peptide - NP_957367
swissprot - Q7ZUY3
ZFIN ID - ZDB-GENE-040426-987
Ensembl - ENSDARG00000029406
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045705Gallus gallus
 ENSGALG00000026449Gallus gallus
 H2AFXENSG00000188486Homo sapiens
 H2afxENSMUSG00000049932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000008655288
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000008868688
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000009859588
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010090688
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010544488
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000005173687
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000009912387
FP340257.1 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000010002487
CU457819.1 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000010027987
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010301587
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010531487
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010540087
si:ch1073-153i20.5 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000010547887
FP236812.2 / H2AFX* / P16104* / H2A histone family member X*ENSDARG0000010992687
CR354435.3 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000011153687
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000011339987
si:ch211-113a14.19 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000011348187
CR354435.4 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000011370787
FP236812.4 / H2AFX* / P16104* / H2A histone family member X*ENSDARG0000011587587
h2afx1 / H2A histone family member X1 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000006899586


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005813 centrosome ISS
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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