ENSMUSG00000061062


Mus musculus

Features
Gene ID: ENSMUSG00000061062
  
Biological name :Gm10093
  
Synonyms : Gm10093
  
Possible biological names infered from orthology : HDAC1 / histone deacetylase 1 / Q13547
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E3
Gene start: 78491565
Gene end: 78493541
  
Corresponding Affymetrix probe sets: 10447004 (MoGene1.0st)   10516605 (MoGene1.0st)   1448246_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078339
MGI - MGI:3704479
swissprot - D3YYI8
Ensembl - ENSMUSG00000061062
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac1ENSDARG00000015427Danio rerio
 HDAC1ENSGALG00000003297Gallus gallus
 HDAC1ENSG00000116478Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdac1 / O09106 / Histone deacetylase 1 / Q13547*ENSMUSG0000002880099
Hdac2 / histone deacetylase 2 / Q92769*ENSMUSG0000001977785
Hdac3 / histone deacetylase 3 / O15379*ENSMUSG0000002445452
Hdac8 / Q8VH37 / Histone deacetylase 8 / Q9BY41*ENSMUSG0000006756733
Hdac11 / Q91WA3 / Histone deacetylase 11 / Q96DB2*ENSMUSG0000003424518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR003084  Histone deacetylase
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
Formation of the beta-catenin:TCF transactivating complex
Downregulation of SMAD2/3:SMAD4 transcriptional activity
HDACs deacetylate histones
Deactivation of the beta-catenin transactivating complex
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042557 Sin3a / Q60520 / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA. / Q96ST3* / SIN3 transcription regulator family member A*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / reaction
 ENSMUSG00000047407 Tgif1 / P70284 / TGFB-induced factor homeobox 1 / Q15583*  / complex / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / complex / reaction
 ENSMUSG00000019777 Hdac2 / histone deacetylase 2 / Q92769*  / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / complex
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / complex / reaction
 ENSMUSG00000008305 Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*  / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / complex / reaction
 ENSMUSG00000032280 Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*  / complex
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000024642 Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*  / complex
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000037896 Rcor1 / Q8CFE3 / REST corepressor 1 / Q9UKL0*  / complex
 ENSMUSG00000029249 Rest / Q8VIG1 / RE1-silencing transcription factor / Q13127*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000034771 Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction
 ENSMUSG00000062175 Tgif2 / Q8C0Y1 / TGFB-induced factor homeobox 2 / Q9GZN2*  / complex / reaction
 ENSMUSG00000049300 Prmt6 / Q6NZB1 / protein arginine N-methyltransferase 6 / Q96LA8* / protein arginine methyltransferase 6*  / complex / reaction
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / reaction






 

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