ENSMUSG00000052997


Mus musculus
enzymeUba2bindingeproteinsumoactivityactivatingubiquitin-activatingsumo-activatingubiquitin-likesitedomainsubunitubaionthif-typenadfadfoldconservedubiquitinc-terminalcysactivesumoylationnucleusnucleoplasmcytoplasmcomplexnucleotide

Features
Gene ID: ENSMUSG00000052997
  
Biological name :Uba2
  
Synonyms : Q9Z1F9 / Uba2 / ubiquitin-like modifier activating enzyme 2
  
Possible biological names infered from orthology : Q9UBT2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 34140688
Gene end: 34169599
  
Corresponding Affymetrix probe sets: 10562331 (MoGene1.0st)   1416280_at (Mouse Genome 430 2.0 Array)   1433440_x_at (Mouse Genome 430 2.0 Array)   1437278_a_at (Mouse Genome 430 2.0 Array)   1448283_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116605
Ensembl peptide - ENSMUSP00000135841
Ensembl peptide - ENSMUSP00000135885
Ensembl peptide - ENSMUSP00000099807
Ensembl peptide - ENSMUSP00000135078
NCBI entrez gene - 50995     See in Manteia.
MGI - MGI:1858313
RefSeq - XM_017322348
RefSeq - NM_016682
RefSeq Peptide - NP_057891
swissprot - H3BLR3
swissprot - H3BJQ2
swissprot - A2BH29
swissprot - Q9Z1F9
swissprot - H3BLM2
Ensembl - ENSMUSG00000052997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uba2ENSDARG00000101332Danio rerio
 UBA2ENSGALG00000005006Gallus gallus
 UBA2ENSG00000126261Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR018074  Ubiquitin-activating enzyme E1, conserved site
 IPR028077  Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
 IPR030661  SUMO-activating enzyme subunit Uba2
 IPR032426  SUMO-activating enzyme subunit 2, C-terminal domain
 IPR033127  Ubiquitin-activating enzyme E1, Cys active site
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processnitrogen compound metabolic processcellular metabolic processcellular metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic processorganic substance metabolic process
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingprotein bindingcarbohydrate derivative bindingdrug bindingligase activitytransferase activityorganic cyclic organic cyclic compound bindingheterocyclic coheterocyclic compound bindingsmall molecule small molecule bindingion bindingion bindingprotein bindingprotein bindingcarbohydrate decarbohydrate derivative bindingdrug bindingdrug bindingligase activityligase activitytransferase acttransferase activity
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031510 SUMO activating enzyme complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016881 acid-amino acid ligase activity IEA
 molecular_functionGO:0019948 SUMO activating enzyme activity IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0044388 small protein activating enzyme binding IEA
 molecular_functionGO:0044390 ubiquitin-like protein conjugating enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052833 Sae1 / Q9R1T2 / SUMO-activating enzyme subunit 1 SUMO-activating enzyme subunit 1, N-terminally processed / Q9UBE0* / SUMO1 activating enzyme subunit 1*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr