ENSG00000103275


Homo sapiens

Features
Gene ID: ENSG00000103275
  
Biological name :UBE2I
  
Synonyms : P63279 / UBE2I / ubiquitin conjugating enzyme E2 I
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 1308880
Gene end: 1327018
  
Corresponding Affymetrix probe sets: 1558088_a_at (Human Genome U133 Plus 2.0 Array)   208760_at (Human Genome U133 Plus 2.0 Array)   211008_s_at (Human Genome U133 Plus 2.0 Array)   213535_s_at (Human Genome U133 Plus 2.0 Array)   233360_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457064
Ensembl peptide - ENSP00000456188
Ensembl peptide - ENSP00000490882
Ensembl peptide - ENSP00000324897
Ensembl peptide - ENSP00000348056
Ensembl peptide - ENSP00000380649
Ensembl peptide - ENSP00000380650
Ensembl peptide - ENSP00000384361
Ensembl peptide - ENSP00000384568
Ensembl peptide - ENSP00000385009
Ensembl peptide - ENSP00000455252
Ensembl peptide - ENSP00000455893
NCBI entrez gene - 7329     See in Manteia.
OMIM - 601661
RefSeq - XM_017023640
RefSeq - NM_003345
RefSeq - NM_194259
RefSeq - NM_194260
RefSeq - NM_194261
RefSeq - XM_005255540
RefSeq - XM_005255541
RefSeq - XM_011522644
RefSeq - XM_011522645
RefSeq Peptide - NP_003336
RefSeq Peptide - NP_919236
RefSeq Peptide - NP_919237
RefSeq Peptide - NP_919235
swissprot - P63279
swissprot - B0QYN7
swissprot - H3BPC4
swissprot - H3BQQ9
swissprot - H3BRD1
Ensembl - ENSG00000103275
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9DDJ0ENSDARG00000052649Danio rerio
 Q9W6H5ENSDARG00000007438Danio rerio
 UBE2IENSGALG00000006428Gallus gallus
 Ube2iENSMUSG00000015120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site
 IPR027230  SUMO-conjugating enzyme Ubc9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway IEA
 biological_processGO:0042359 vitamin D metabolic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 biological_processGO:1903755 positive regulation of SUMO transferase activity IDA
 cellular_componentGO:0000795 synaptonemal complex TAS
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:1990234 transferase complex IDA
 cellular_componentGO:1990356 sumoylated E2 ligase complex IC
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0043398 HLH domain binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0044388 small protein activating enzyme binding IPI
 molecular_functionGO:0061656 SUMO conjugating enzyme activity IDA
 molecular_functionGO:0071535 RING-like zinc finger domain binding IPI


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127663 KDM4B / O94953 / lysine demethylase 4B  / reaction
 ENSG00000088305 DNMT3B / Q9UBC3 / DNA methyltransferase 3 beta  / reaction
 ENSG00000087510 Q92754 / TFAP2C / transcription factor AP-2 gamma  / reaction
 ENSG00000094916 CBX5 / P45973 / chromobox 5  / reaction
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / reaction
 ENSG00000108654 DDX5 / P17844 / DEAD-box helicase 5  / reaction
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / reaction
 ENSG00000116833 NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2  / reaction
 ENSG00000130726 Q13263 / TRIM28 / tripartite motif containing 28  / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / reaction
 ENSG00000131759 RARA / P10276 / retinoic acid receptor alpha  / reaction
 ENSG00000126261 UBA2 / Q9UBT2 / ubiquitin like modifier activating enzyme 2  / reaction
 ENSG00000256683 Q9GZX5 / ZNF350 / zinc finger protein 350  / reaction
 ENSG00000082175 PGR / P06401 / progesterone receptor  / reaction
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / reaction
 ENSG00000139372 TDG / Q13569 / thymine DNA glycosylase  / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction
 ENSG00000186951 PPARA / Q07869 / peroxisome proliferator activated receptor alpha  / reaction
 ENSG00000134086 VHL / P40337 / von Hippel-Lindau tumor suppressor  / reaction
 ENSG00000055044 NOP58 / Q9Y2X3 / NOP58 ribonucleoprotein  / reaction
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / reaction
 ENSG00000204209 DAXX / Q9UER7 / death domain associated protein  / reaction
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / reaction
 ENSG00000077097 TOP2B / Q02880 / DNA topoisomerase II beta  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / reaction
 ENSG00000151090 THRB / P10828 / thyroid hormone receptor beta  / reaction
 ENSG00000141644 MBD1 / Q9UIS9 / methyl-CpG binding domain protein 1  / reaction
 ENSG00000084676 NCOA1 / Q15788 / nuclear receptor coactivator 1  / reaction
 ENSG00000160633 SAFB / Q15424 / scaffold attachment factor B  / reaction
 ENSG00000154767 XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor  / reaction
 ENSG00000165392 WRN / Q14191 / Werner syndrome RecQ like helicase  / reaction
 ENSG00000132170 PPARG / P37231 / peroxisome proliferator activated receptor gamma  / reaction
 ENSG00000140464 PML / P29590 / promyelocytic leukemia  / reaction
 ENSG00000142230 SAE1 / Q9UBE0 / SUMO1 activating enzyme subunit 1  / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000181163 NPM1 / P06748 / nucleophosmin 1  / reaction
 ENSG00000159692 CTBP1 / Q13363 / C-terminal binding protein 1  / reaction
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction
 ENSG00000130816 DNMT1 / P26358 / DNA methyltransferase 1  / reaction
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / complex / reaction
 ENSG00000120798 NR2C1 / P13056 / nuclear receptor subfamily 2 group C member 1  / reaction
 ENSG00000153234 NR4A2 / P43354 / nuclear receptor subfamily 4 group A member 2  / reaction
 ENSG00000183770 FOXL2 / P58012 / forkhead box L2  / reaction
 ENSG00000180530 NRIP1 / P48552 / nuclear receptor interacting protein 1  / reaction
 ENSG00000116288 PARK7 / Q99497 / Parkinsonism associated deglycase  / reaction
 ENSG00000064393 HIPK2 / Q9H2X6 / homeodomain interacting protein kinase 2  / reaction
 ENSG00000170004 CHD3 / Q12873 / chromodomain helicase DNA binding protein 3  / reaction
 ENSG00000100201 DDX17 / Q92841 / DEAD-box helicase 17  / reaction
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / reaction
 ENSG00000012504 NR1H4 / Q96RI1 / nuclear receptor subfamily 1 group H member 4  / reaction
 ENSG00000111424 VDR / P11473 / vitamin D receptor  / reaction
 ENSG00000002016 RAD52 / P43351 / RAD52 homolog, DNA repair protein  / reaction
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / reaction
 ENSG00000113580 NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1  / reaction
 ENSG00000119042 SATB2 / Q9UPW6 / SATB homeobox 2  / reaction
 ENSG00000067066 SP100 / P23497 / SP100 nuclear antigen  / reaction
 ENSG00000119772 DNMT3A / Q9Y6K1 / DNA methyltransferase 3 alpha  / reaction
 ENSG00000069667 RORA / P35398 / RAR related orphan receptor A  / reaction
 ENSG00000126351 THRA / P10827 / thyroid hormone receptor, alpha  / reaction
 ENSG00000172845 SP3 / Q02447 / Sp3 transcription factor  / reaction
 ENSG00000168556 ING2 / Q9H160 / inhibitor of growth family member 2  / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction
 ENSG00000152422 XRCC4 / Q13426 / X-ray repair cross complementing 4  / reaction
 ENSG00000153201 P49792 / RANBP2 / RAN binding protein 2  / complex / reaction
 ENSG00000172262 P52739 / ZNF131 / zinc finger protein 131  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000137203 P05549 / TFAP2A / transcription factor AP-2 alpha  / reaction
 ENSG00000182979 MTA1 / Q13330 / metastasis associated 1  / reaction
 ENSG00000151623 NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2  / reaction
 ENSG00000187098 MITF / O75030 / melanogenesis associated transcription factor  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction
 ENSG00000144852 NR1I2 / O75469 / nuclear receptor subfamily 1 group I member 2  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction / complex
 ENSG00000068024 HDAC4 / P56524 / histone deacetylase 4  / reaction
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / reaction
 ENSG00000169375 SIN3A / Q96ST3 / SIN3 transcription regulator family member A  / reaction
 ENSG00000197299 BLM / P54132 / Bloom syndrome RecQ like helicase  / reaction
 ENSG00000136931 NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1  / reaction
 ENSG00000196591 HDAC2 / Q92769 / histone deacetylase 2  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / reaction
 ENSG00000131747 TOP2A / P11388 / DNA topoisomerase II alpha  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000177374 HIC1 / Q14526 / HIC ZBTB transcriptional repressor 1  / reaction
 ENSG00000182568 SATB1 / Q01826 / SATB homeobox 1  / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000092199 HNRNPC / P07910 / heterogeneous nuclear ribonucleoprotein C (C1/C2)  / reaction
 ENSG00000198900 TOP1 / P11387 / DNA topoisomerase I  / reaction
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / reaction
 ENSG00000196588 MKL1 / Q969V6 / megakaryoblastic leukemia (translocation) 1  / reaction
 ENSG00000100401 P46060 / RANGAP1 / Ran GTPase activating protein 1  / complex
 ENSG00000197579 Q9NS56 / TOPORS / TOP1 binding arginine/serine rich protein  / reaction
 ENSG00000165119 HNRNPK / P61978 / heterogeneous nuclear ribonucleoprotein K  / reaction
 ENSG00000008196 Q92481 / TFAP2B / transcription factor AP-2 beta  / reaction
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / reaction
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / reaction
 ENSG00000147400 CETN2 / P41208 / centrin 2  / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000169083 AR / P10275 / androgen receptor  / reaction
 ENSG00000066135 KDM4A / O75164 / lysine demethylase 4A  / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction
 ENSG00000140396 NCOA2 / Q15596 / nuclear receptor coactivator 2  / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / reaction






 

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