ENSG00000153201


Homo sapiens

Features
Gene ID: ENSG00000153201
  
Biological name :RANBP2
  
Synonyms : P49792 / RAN binding protein 2 / RANBP2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q13
Gene start: 108719481
Gene end: 108785811
  
Corresponding Affymetrix probe sets: 201711_x_at (Human Genome U133 Plus 2.0 Array)   201712_s_at (Human Genome U133 Plus 2.0 Array)   201713_s_at (Human Genome U133 Plus 2.0 Array)   226922_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000283195
Ensembl peptide - ENSP00000398970
Ensembl peptide - ENSP00000485979
NCBI entrez gene - 5903     See in Manteia.
OMIM - 601181
RefSeq - XM_017004624
RefSeq - NM_006267
RefSeq - XM_011511576
RefSeq - XM_011511578
RefSeq - XM_017004623
RefSeq - XM_005264002
RefSeq - XM_005264003
RefSeq - XM_005264004
RefSeq - XM_005264005
RefSeq - XM_005264007
RefSeq - XM_011511575
RefSeq Peptide - NP_006258
swissprot - P49792
swissprot - F8WBP7
Ensembl - ENSG00000153201
  
Related genetic diseases (OMIM): 608033 - {Encephalopathy, acute, infection-induced, 3, susceptibility to}, 608033
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RANBP2ENSDARG00000093125Danio rerio
 ENSGALG00000016808Gallus gallus
 Q9ERU9ENSMUSG00000003226Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RGPD5 / Q99666 / RANBP2-like and GRIP domain containing 5ENSG0000001556850
RGPD3 / A6NKT7 / RANBP2-like and GRIP domain containing 3ENSG0000015316550
RGPD8 / O14715 / RANBP2-like and GRIP domain containing 8ENSG0000016962950
RGPD6 / Q99666 / RANBP2-like and GRIP domain containing 6ENSG0000018305450
RGPD4 / Q7Z3J3 / RANBP2-like and GRIP domain containing 4ENSG0000019686250
RGPD2 / P0DJD1 / RANBP2-like and GRIP domain containing 2ENSG0000018530449
RGPD1 / P0DJD0 / RANBP2-like and GRIP domain containing 1ENSG0000018762749
PPIE / Q9UNP9 / peptidylprolyl isomerase EENSG000000840724
PPIF / P30405 / peptidylprolyl isomerase FENSG000001081794
PPIA / P62937 / peptidylprolyl isomerase AENSG000001962623
P0DN37 / PPIAL4G / peptidylprolyl isomerase A like 4GENSG000002363343
F5H284 / PPIAL4D / peptidylprolyl isomerase A like 4DENSG000002563743
Q9Y536 / PPIAL4A / peptidylprolyl isomerase A like 4AENSG000002633533
PPIAL4C / A0A0B4J2A2 / peptidylprolyl isomerase A like 4CENSG000002634643
AC243756.1ENSG000002703393
PPIAL4E / A0A075B759 / peptidylprolyl isomerase A like 4EENSG000002715673
P0DN26 / PPIAL4F / peptidylprolyl isomerase A like 4FENSG000002797823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000156  Ran binding domain
 IPR001876  Zinc finger, RanBP2-type
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR011993  PH-like domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR022011  Nup358/RanBP2 E3 ligase domain
 IPR029000  Cyclophilin-like domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0006110 regulation of glycolytic process TAS
 biological_processGO:0006405 RNA export from nucleus IBA
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006409 tRNA export from nucleus TAS
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IMP
 biological_processGO:0007051 spindle organization IBA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0019083 viral transcription TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046604 positive regulation of mitotic centrosome separation IBA
 biological_processGO:0046907 intracellular transport IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005642 annulate lamellae IDA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0042405 nuclear inclusion body IDA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0044614 nuclear pore cytoplasmic filaments IDA
 cellular_componentGO:0044615 nuclear pore nuclear basket IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008536 Ran GTPase binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity EXP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
RHO GTPases Activate Formins
tRNA processing in the nucleus
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / complex / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000100401 P46060 / RANGAP1 / Ran GTPase activating protein 1  / complex






 

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