ENSG00000188612


Homo sapiens

Features
Gene ID: ENSG00000188612
  
Biological name :SUMO2
  
Synonyms : P61956 / small ubiquitin-like modifier 2 / SUMO2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.1
Gene start: 75165586
Gene end: 75182983
  
Corresponding Affymetrix probe sets: 208738_x_at (Human Genome U133 Plus 2.0 Array)   208739_x_at (Human Genome U133 Plus 2.0 Array)   211444_at (Human Genome U133 Plus 2.0 Array)   213881_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461997
Ensembl peptide - ENSP00000400886
Ensembl peptide - ENSP00000405965
NCBI entrez gene - 6613     See in Manteia.
OMIM - 603042
RefSeq - NM_006937
RefSeq - NM_001005849
RefSeq Peptide - NP_001005849
RefSeq Peptide - NP_008868
swissprot - P61956
swissprot - A0A024R8S3
swissprot - J3KRH1
Ensembl - ENSG00000188612
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DHL4ENSDARG00000102741Danio rerio
 SUMO2ENSGALG00000007971Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SUMO3 / P55854 / small ubiquitin-like modifier 3ENSG0000018490096
SUMO4 / Q6EEV6 / small ubiquitin-like modifier 4ENSG0000017768885
SUMO1 / P63165 / small ubiquitin-like modifier 1ENSG0000011603053


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR022617  Rad60/SUMO-like domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033950  Sumo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0042359 vitamin D metabolic process TAS
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0001222 transcription corepressor binding IPI
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031386 protein tag IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108654 DDX5 / P17844 / DEAD-box helicase 5  / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / reaction / complex
 ENSG00000131759 RARA / P10276 / retinoic acid receptor alpha  / reaction
 ENSG00000139372 TDG / Q13569 / thymine DNA glycosylase  / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / reaction / complex
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / complex / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000160633 SAFB / Q15424 / scaffold attachment factor B  / reaction
 ENSG00000163904 SENP2 / Q9HC62 / SUMO1/sentrin/SMT3 specific peptidase 2  / reaction
 ENSG00000142230 SAE1 / Q9UBE0 / SUMO1 activating enzyme subunit 1  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction / complex
 ENSG00000159692 CTBP1 / Q13363 / C-terminal binding protein 1  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction / complex
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / - / reaction
 ENSG00000153234 NR4A2 / P43354 / nuclear receptor subfamily 4 group A member 2  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction / complex
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction / complex
 ENSG00000182568 SATB1 / Q01826 / SATB homeobox 1  / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / reaction
 ENSG00000111424 VDR / P11473 / vitamin D receptor  / reaction
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / reaction
 ENSG00000126261 UBA2 / Q9UBT2 / ubiquitin like modifier activating enzyme 2  / complex / reaction
 ENSG00000067066 SP100 / P23497 / SP100 nuclear antigen  / reaction
 ENSG00000055044 NOP58 / Q9Y2X3 / NOP58 ribonucleoprotein  / reaction
 ENSG00000069667 RORA / P35398 / RAR related orphan receptor A  / reaction
 ENSG00000172845 SP3 / Q02447 / Sp3 transcription factor  / reaction
 ENSG00000154767 XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor  / complex
 ENSG00000153201 P49792 / RANBP2 / RAN binding protein 2  / reaction
 ENSG00000140464 PML / P29590 / promyelocytic leukemia  / reaction
 ENSG00000181163 NPM1 / P06748 / nucleophosmin 1  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000182979 MTA1 / Q13330 / metastasis associated 1  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / - / complex / reaction
 ENSG00000068024 HDAC4 / P56524 / histone deacetylase 4  / reaction
 ENSG00000197299 BLM / P54132 / Bloom syndrome RecQ like helicase  / reaction
 ENSG00000136931 NR5A1 / Q13285 / nuclear receptor subfamily 5 group A member 1  / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / reaction
 ENSG00000131747 TOP2A / P11388 / DNA topoisomerase II alpha  / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000119231 SENP5 / Q96HI0 / SUMO1/sentrin specific peptidase 5  / reaction
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / reaction
 ENSG00000119318 P54727 / RAD23B / RAD23 homolog B, nucleotide excision repair protein  / complex
 ENSG00000165119 HNRNPK / P61978 / heterogeneous nuclear ribonucleoprotein K  / reaction
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / reaction
 ENSG00000147400 CETN2 / P41208 / centrin 2  / complex / reaction
 ENSG00000079387 SENP1 / Q9P0U3 / SUMO1/sentrin specific peptidase 1  / reaction






 

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