ENSG00000131747
Homo sapiens dna TOP2A binding topoisomerase type domain protein iia regulation activity subunit chromosome c-terminal complex ii kinase atpase toprim superfamily process viral replication rna histidine hsp -like b ribosomal s -type fold
Features Gene ID: ENSG00000131747 Biological name :TOP2A Synonyms : DNA topoisomerase II alpha / / Possible biological names infered from orthology : Species: Homo sapiens Chr. number: 17 Strand: -1 Band: q21.2 Gene start: 40388516 Gene end: 40417950 Corresponding Affymetrix probe sets: 201291_s_at (Human Genome U133 Plus 2.0 Array) 201292_at (Human Genome U133 Plus 2.0 Array) 237469_at (Human Genome U133 Plus 2.0 Array) Cross references: Ensembl peptide - ENSP000004115327153
See in Manteia .
126430 XM_011525165 NM_001067 XM_005257632 NP_001058 P11388 J3QR57 J3KTB7 ENSG00000131747 Related genetic diseases (OMIM): 126430 - DNA topoisomerase II, resistance to inhibition of, by amsacrine
See expression report in BioGPS See gene description in Wikigenes See gene description in GeneCards See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl )Protein motifs (from Interpro ) IPR001154 DNA topoisomerase II, eukaryotic-type IPR001241 DNA topoisomerase, type IIA IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal IPR003594 Histidine kinase/HSP90-like ATPase IPR006171 TOPRIM domain IPR012542 DTHCT IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal IPR013760 DNA topoisomerase, type IIA-like domain superfamily IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup IPR018522 DNA topoisomerase, type IIA, conserved site IPR020568 Ribosomal protein S5 domain 2-type fold IPR031660 C-terminal associated domain of TOPRIM IPR034157 DNA topoisomerase 2, TOPRIM domain IPR036890 Histidine kinase/HSP90-like ATPase superfamily
Gene Ontology (GO ) nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process organic substance metabolic process cell cycle chromosome segregation anatomical structure development cellular developmental process response to stress cellular response to stimulus cell death cell division circadian rhythm interspecies interaction between organisms biosynthetic process nitrogennitrogen compound metabolic process cellularcellular component organization cellularcellular metabolic process primary primary metabolic process organic organic substance metabolic process cell cyccell cycle chromosochromosome segregation anatomicanatomical structure development cellularcellular developmental process responseresponse to stress cellularcellular response to stimulus cell deacell death cell divcell division circadiacircadian rhythm interspeinterspecies interaction between organisms biosynthbiosynthetic process organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding chromatin binding catalytic activity, acting on DNA isomerase activity hydrolase activity protein binding carbohydrate derivative binding drug binding organic cyclorganic cyclic compound binding heterocyclicheterocyclic compound binding small molecusmall molecule binding ion bindingion binding chromatin bichromatin binding catalytic accatalytic activity, acting on DNA isomerase acisomerase activity hydrolase achydrolase activity protein bindprotein binding carbohydratecarbohydrate derivative binding drug bindingdrug binding cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cell organelle membrane-enclosed lumen protein-containing complex other organism cellcell organelleorganelle membrane-enclosed lumenmembrane-enclosed lumen protein-containing complexprotein-containing complex other organismother organism
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality Neoplasia Neurological abnormality Metabolism abnormality Genitourinary abnormality NeoplasiaNeoplasia Neurological abnormalityNeurological abnormality Metabolism abnormalityMetabolism abnormality Genitourinary abnormalityGenitourinary abnormality HP:0004375 Neoplasia of the nervous system
Show HP:0011976 Elevated urinary catecholamines "An increased concentration of `catecholamine` (CHEBI:33567) in the urine." [HPO:probinson]
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Interacting proteins (from Reactome ) ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3 / reaction ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I / reaction ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2 / reaction ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1 / reaction / complex
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