Manteia

ENSG00000105229

Homo sapiens

Features

Gene ID:	ENSG00000105229

Biological name :	PIAS4

Synonyms :	PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	19
Strand:	1
Band:	p13.3
Gene start:	4007646
Gene end:	4039386

Corresponding Affymetrix probe sets:	212879_x_at (Human Genome U133 Plus 2.0 Array) 212881_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000262971 NCBI entrez gene - 51588 See in Manteia. OMIM - 605989 RefSeq - XM_017026868 RefSeq - NM_015897 RefSeq - XM_011528060 RefSeq Peptide - NP_056981 swissprot - Q8N2W9 Ensembl - ENSG00000105229

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pias4a	ENSDARG00000007081	Danio rerio
pias4b	ENSDARG00000042215	Danio rerio
PIAS4	ENSGALG00000034413	Gallus gallus
Pias4	ENSMUSG00000004934	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PIAS2 / O75928 / protein inhibitor of activated STAT 2	ENSG00000078043	48
PIAS1 / O75925 / protein inhibitor of activated STAT 1	ENSG00000033800	47
PIAS3 / Q9Y6X2 / protein inhibitor of activated STAT 3	ENSG00000131788	46
ZMIZ2 / Q8NF64 / zinc finger MIZ-type containing 2	ENSG00000122515	22
ZMIZ1 / Q9ULJ6 / zinc finger MIZ-type containing 1	ENSG00000108175	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR003034	SAP domain
IPR004181	Zinc finger, MIZ-type
IPR023321	PINIT domain
IPR027224	E3 SUMO-protein ligase PIAS4
IPR036361	SAP domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	TAS
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	IEA
biological_process	GO:0016055	Wnt signaling pathway	IEA
biological_process	GO:0016925	protein sumoylation	IDA
biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IEA
biological_process	GO:0033235	positive regulation of protein sumoylation	IDA
biological_process	GO:0042359	vitamin D metabolic process	TAS
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	NAS
biological_process	GO:1902174	positive regulation of keratinocyte apoptotic process	IEA
biological_process	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA
cellular_component	GO:0005634	nucleus	NAS
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0016363	nuclear matrix	IEA
cellular_component	GO:0016605	PML body	IEA
cellular_component	GO:1990234	transferase complex	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003714	transcription corepressor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008022	protein C-terminus binding	IEA
molecular_function	GO:0008270	zinc ion binding	NAS
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019789	SUMO transferase activity	IMP
molecular_function	GO:0031625	ubiquitin protein ligase binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0061665	SUMO ligase activity	IEA

Pathways (from Reactome)

Pathway description

Vitamin D (calciferol) metabolism

SUMOylation of DNA damage response and repair proteins

SUMOylation of transcription factors

SUMOylation of ubiquitinylation proteins

SUMOylation of transcription cofactors

SUMOylation of SUMOylation proteins

SUMOylation of intracellular receptors

SUMOylation of DNA replication proteins

SUMOylation of immune response proteins

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Nonhomologous End-Joining (NHEJ)

Processing of DNA double-strand break ends

G2/M DNA damage checkpoint

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000011485	PPP5C / P53041 / protein phosphatase 5 catalytic subunit	/ reaction
ENSG00000127663	KDM4B / O94953 / lysine demethylase 4B	/ complex / reaction
ENSG00000112130	RNF8 / O76064 / ring finger protein 8	/ complex / reaction
ENSG00000080345	RIF1 / Q5UIP0 / replication timing regulatory factor 1	/ complex / reaction
ENSG00000128731	HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2	/ complex / reaction
ENSG00000104320	NBN / nibrin / O60934	/ complex / reaction
ENSG00000067369	Q12888 / TP53BP1 / tumor protein p53 binding protein 1	/ complex / reaction
ENSG00000103275	UBE2I / P63279 / ubiquitin conjugating enzyme E2 I	/ reaction
ENSG00000183765	CHEK2 / O96017 / checkpoint kinase 2	/ complex / reaction
ENSG00000163961	Q8IYW5 / RNF168 / ring finger protein 168	/ complex / reaction
ENSG00000177889	UBE2N / P61088 / ubiquitin conjugating enzyme E2 N	/ complex / reaction
ENSG00000188612	SUMO2 / P61956 / small ubiquitin-like modifier 2	/ reaction / complex
ENSG00000116030	SUMO1 / P63165 / small ubiquitin-like modifier 1	/ complex / reaction
ENSG00000157212	PAXIP1 / Q6ZW49 / PAX interacting protein 1	/ complex / reaction
ENSG00000169139	Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2	/ complex / reaction
ENSG00000109685	NSD2 / O96028 / nuclear receptor binding SET domain protein 2	/ complex / reaction
ENSG00000149311	ATM / Q13315 / ATM serine/threonine kinase	/ complex / reaction
ENSG00000020922	MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease	/ complex / reaction
ENSG00000172977	KAT5 / Q92993 / lysine acetyltransferase 5	/ complex / reaction
ENSG00000163322	Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit	/ complex / reaction
ENSG00000196419	XRCC6 / P12956 / X-ray repair cross complementing 6	/ reaction
ENSG00000152457	Q96SD1 / DCLRE1C / DNA cross-link repair 1C	/ complex / reaction
ENSG00000168148	Q16695 / HIST3H3 / histone cluster 3 H3	/ complex / reaction
ENSG00000066135	KDM4A / O75164 / lysine demethylase 4A	/ complex / reaction
ENSG00000188486	H2AFX / P16104 / H2A histone family member X	/ complex / reaction
ENSG00000137337	MDC1 / Q14676 / mediator of DNA damage checkpoint 1	/ complex / reaction
ENSG00000079246	XRCC5 / P13010 / X-ray repair cross complementing 5	/ reaction
ENSG00000087206	UIMC1 / Q96RL1 / ubiquitin interaction motif containing 1	/ complex / reaction
ENSG00000113522	RAD50 / Q92878 / RAD50 double strand break repair protein	/ complex / reaction
ENSG00000276180	P62805 / HIST1H4I / histone cluster 1 H4 family member i	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr