ENSG00000127663


Homo sapiens

Features
Gene ID: ENSG00000127663
  
Biological name :KDM4B
  
Synonyms : KDM4B / lysine demethylase 4B / O94953
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 4969113
Gene end: 5153595
  
Corresponding Affymetrix probe sets: 1559073_at (Human Genome U133 Plus 2.0 Array)   212492_s_at (Human Genome U133 Plus 2.0 Array)   212495_at (Human Genome U133 Plus 2.0 Array)   212496_s_at (Human Genome U133 Plus 2.0 Array)   215616_s_at (Human Genome U133 Plus 2.0 Array)   216023_at (Human Genome U133 Plus 2.0 Array)   230126_s_at (Human Genome U133 Plus 2.0 Array)   235789_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468514
Ensembl peptide - ENSP00000467678
Ensembl peptide - ENSP00000480642
Ensembl peptide - ENSP00000159111
Ensembl peptide - ENSP00000371178
Ensembl peptide - ENSP00000440495
NCBI entrez gene - 23030     See in Manteia.
OMIM - 609765
RefSeq - XM_017026505
RefSeq - XM_011527819
RefSeq - XM_011527820
RefSeq - XM_011527821
RefSeq - XM_011527822
RefSeq - XM_017026503
RefSeq - XM_017026504
RefSeq - NM_015015
RefSeq - XM_005259521
RefSeq - XM_011527814
RefSeq - XM_011527817
RefSeq - XM_011527818
RefSeq Peptide - NP_055830
swissprot - F5GX28
swissprot - K7EQ54
swissprot - K7ES23
swissprot - A0A0C4DFL8
swissprot - O94953
Ensembl - ENSG00000127663
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm4bENSDARG00000099675Danio rerio
 ENSGALG00000034592Gallus gallus
 Kdm4bENSMUSG00000024201Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM4C / Q9H3R0 / lysine demethylase 4CENSG0000010707752
KDM4A / O75164 / lysine demethylase 4AENSG0000006613549
KDM4F / lysine demethylase 4FENSG0000025585526
KDM4D / Q6B0I6 / lysine demethylase 4DENSG0000018628025
KDM4E / B2RXH2 / lysine demethylase 4EENSG0000023526824
AL451062.3ENSG0000028498915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0033169 histone H3-K9 demethylation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IDA
 biological_processGO:1900113 negative regulation of histone H3-K9 trimethylation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0031618 nuclear pericentric heterochromatin IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IDA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / complex / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / complex / reaction
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / complex / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / complex / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction






 

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