ENSDARG00000099675


Danio rerio

Features
Gene ID: ENSDARG00000099675
  
Biological name :kdm4b
  
Synonyms : kdm4b / lysine (K)-specific demethylase 4B
  
Possible biological names infered from orthology : lysine demethylase 4B / Lysine-specific demethylase 4B / O94953 / Q91VY5
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 4313605
Gene end: 4407871
  
Corresponding Affymetrix probe sets: Dr.18485.1.A1_at (Zebrafish Array)   Dr.18485.2.A1_at (Zebrafish Array)   Dr.18485.2.A1_a_at (Zebrafish Array)   Dr.18485.2.A1_x_at (Zebrafish Array)   NM_001082805_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000133766
Ensembl peptide - ENSDARP00000156548
NCBI entrez gene - 556504     See in Manteia.
RefSeq - XM_021469327
RefSeq - NM_001082805
RefSeq Peptide - NP_001076274
swissprot - Q1LUQ0
ZFIN ID - ZDB-GENE-060503-664
Ensembl - ENSDARG00000099675
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000034592Gallus gallus
 KDM4BENSG00000127663Homo sapiens
 Kdm4bENSMUSG00000024201Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kdm4c / lysine (K)-specific demethylase 4C / Q8VCD7* / Q9H3R0* / lysine demethylase 4C* / Mus musculus lysine (K)-specific demethylase 4C (Kdm4c), transcript variant 3, mRNA.*ENSDARG0000006150444
kdm4aa / lysine (K)-specific demethylase 4A, genome duplicate a / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *ENSDARG0000001878242
kdm4ab / lysine (K)-specific demethylase 4A, genome duplicate b / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *ENSDARG0000001910342


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000026225 nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex / reaction
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000028198 Q6PEH5 / ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000044949 rnf8 / ring finger protein 8, E3 ubiquitin protein ligase / Q8VC56* / O76064* / Gm28043* / ring finger protein 8* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000073841 herc2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSDARG00000086764 mdc1 / mediator of DNA damage checkpoint 1 / Q14676*  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000042215 pias4b / protein inhibitor of activated STAT, 4b / PIAS4* / Q9JM05* / Q8N2W9* / protein inhibitor of activated STAT 4*  / complex / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / complex / reaction
 ENSDARG00000105345 zgc:173552  / complex / reaction
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / complex / reaction
 ENSDARG00000112483 rnf168 / ring finger protein 168 / Q8IYW5*  / complex / reaction






 

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