Manteia

ENSG00000177889

Homo sapiens

Features

Gene ID:	ENSG00000177889

Biological name :	UBE2N

Synonyms :	P61088 / UBE2N / ubiquitin conjugating enzyme E2 N

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	12
Strand:	-1
Band:	q22
Gene start:	93405673
Gene end:	93442262

Corresponding Affymetrix probe sets:	201523_x_at (Human Genome U133 Plus 2.0 Array) 201524_x_at (Human Genome U133 Plus 2.0 Array) 212751_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000316176 Ensembl peptide - ENSP00000448352 Ensembl peptide - ENSP00000449352 Ensembl peptide - ENSP00000450260 Ensembl peptide - ENSP00000447009 NCBI entrez gene - 7334 See in Manteia. OMIM - 603679 RefSeq - NM_003348 RefSeq Peptide - NP_003339 swissprot - V9HW41 swissprot - F8VQQ8 swissprot - F8VSD4 swissprot - F8VV71 swissprot - F8VZ29 swissprot - P61088 Ensembl - ENSG00000177889

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ube2na	ENSDARG00000008748	Danio rerio
ube2nb	ENSDARG00000045877	Danio rerio
UBE2N	ENSGALG00000030515	Gallus gallus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
UBE2NL / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)	ENSG00000276380	53
UBE2T / Q9NPD8 / ubiquitin conjugating enzyme E2 T	ENSG00000077152	45

Protein motifs (from Interpro)

Interpro ID	Name
IPR000608	Ubiquitin-conjugating enzyme E2
IPR016135	Ubiquitin-conjugating enzyme/RWD-like
IPR023313	Ubiquitin-conjugating enzyme, active site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000187	activation of MAPK activity	TAS
biological_process	GO:0000724	double-strand break repair via homologous recombination	IMP
biological_process	GO:0000729	DNA double-strand break processing	IMP
biological_process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006282	regulation of DNA repair	TAS
biological_process	GO:0006301	postreplication repair	IMP
biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	TAS
biological_process	GO:0006464	cellular protein modification process	TAS
biological_process	GO:0006508	proteolysis	TAS
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0007254	JNK cascade	TAS
biological_process	GO:0016567	protein ubiquitination	IMP
biological_process	GO:0016574	histone ubiquitination	IMP
biological_process	GO:0031058	positive regulation of histone modification	IMP
biological_process	GO:0033182	regulation of histone ubiquitination	IMP
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP
biological_process	GO:0045739	positive regulation of DNA repair	IMP
biological_process	GO:0050852	T cell receptor signaling pathway	IMP
biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TAS
biological_process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	IMP
biological_process	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	TAS
biological_process	GO:0070498	interleukin-1-mediated signaling pathway	TAS
biological_process	GO:0070534	protein K63-linked ubiquitination	IMP
biological_process	GO:0070911	global genome nucleotide-excision repair	TAS
cellular_component	GO:0000151	ubiquitin ligase complex	IDA
cellular_component	GO:0001650	fibrillar center	IDA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	TAS
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0031372	UBC13-MMS2 complex	IDA
cellular_component	GO:0032991	protein-containing complex	IDA
cellular_component	GO:0035370	UBC13-UEV1A complex	IDA
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003723	RNA binding	HDA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0031625	ubiquitin protein ligase binding	IBA
molecular_function	GO:0043130	ubiquitin binding	IDA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IBA

Pathways (from Reactome)

Pathway description

ISG15 antiviral mechanism

NOD1/2 Signaling Pathway

TICAM1, RIP1-mediated IKK complex recruitment

Downstream TCR signaling

FCERI mediated NF-kB activation

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

activated TAK1 mediates p38 MAPK activation

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

CLEC7A (Dectin-1) signaling

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Nonhomologous End-Joining (NHEJ)

Processing of DNA double-strand break ends

Formation of Incision Complex in GG-NER

G2/M DNA damage checkpoint

E3 ubiquitin ligases ubiquitinate target proteins

Interleukin-1 signaling

IRAK1 recruits IKK complex

IKK complex recruitment mediated by RIP1

TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Antigen processing: Ubiquitination & Proteasome degradation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000011485	PPP5C / P53041 / protein phosphatase 5 catalytic subunit	/ reaction
ENSG00000127663	KDM4B / O94953 / lysine demethylase 4B	/ complex / reaction
ENSG00000100324	TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1	/ complex
ENSG00000112130	RNF8 / O76064 / ring finger protein 8	/ reaction / complex
ENSG00000080345	RIF1 / Q5UIP0 / replication timing regulatory factor 1	/ complex / reaction
ENSG00000128731	HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2	/ reaction / complex
ENSG00000104320	NBN / nibrin / O60934	/ complex / reaction
ENSG00000105229	PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4	/ complex / reaction
ENSG00000067369	Q12888 / TP53BP1 / tumor protein p53 binding protein 1	/ complex / reaction
ENSG00000157625	TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3	/ complex
ENSG00000109685	NSD2 / O96028 / nuclear receptor binding SET domain protein 2	/ complex / reaction
ENSG00000176641	Q8N8N0 / RNF152 / ring finger protein 152	/ complex / reaction
ENSG00000149311	ATM / Q13315 / ATM serine/threonine kinase	/ complex / reaction
ENSG00000020922	MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease	/ complex / reaction
ENSG00000244687	Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1	/ complex / reaction
ENSG00000183765	CHEK2 / O96017 / checkpoint kinase 2	/ reaction / complex
ENSG00000163961	Q8IYW5 / RNF168 / ring finger protein 168	/ complex / reaction
ENSG00000172977	KAT5 / Q92993 / lysine acetyltransferase 5	/ complex / reaction
ENSG00000101916	TLR8 / Q9NR97 / toll like receptor 8	/ reaction
ENSG00000119048	UBE2B / P63146 / ubiquitin conjugating enzyme E2 B	/ complex / reaction
ENSG00000070950	RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase	/ complex / reaction
ENSG00000138646	HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5	/ reaction
ENSG00000139946	PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2	/ complex / reaction
ENSG00000146414	SHPRH / Q149N8 / SNF2 histone linker PHD RING helicase	/ complex / reaction
ENSG00000140992	PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1	/ reaction
ENSG00000071794	HLTF / Q14527 / helicase like transcription factor	/ complex / reaction
ENSG00000156587	O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6	/ reaction
ENSG00000103275	UBE2I / P63279 / ubiquitin conjugating enzyme E2 I	/ reaction
ENSG00000177889	UBE2N / P61088 / ubiquitin conjugating enzyme E2 N	/ complex / reaction
ENSG00000188612	SUMO2 / P61956 / small ubiquitin-like modifier 2	/ reaction / complex
ENSG00000185507	IRF7 / Q92985 / interferon regulatory factor 7	/ reaction
ENSG00000197329	PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1	/ complex / reaction
ENSG00000172175	MALT1 / Q9UDY8 / MALT1 paracaspase	/ reaction
ENSG00000198286	CARD11 / Q9BXL7 / caspase recruitment domain family member 11	/ reaction
ENSG00000239732	TLR9 / Q9NR96 / toll like receptor 9	/ reaction
ENSG00000175104	TRAF6 / Q9Y4K3 / TNF receptor associated factor 6	/ complex / reaction
ENSG00000184216	IRAK1 / P51617 / interleukin 1 receptor associated kinase 1	/ complex / reaction
ENSG00000142867	BCL10 / O95999 / B cell CLL/lymphoma 10	/ reaction
ENSG00000116030	SUMO1 / P63165 / small ubiquitin-like modifier 1	/ complex / reaction
ENSG00000155876	RRAGA / Q7L523 / Ras related GTP binding A	/ complex / reaction
ENSG00000132646	PCNA / P12004 / proliferating cell nuclear antigen	/ complex / reaction
ENSG00000187608	ISG15 / P05161 / ISG15 ubiquitin-like modifier	/ complex / reaction
ENSG00000196664	TLR7 / Q9NYK1 / toll like receptor 7	/ reaction
ENSG00000166233	ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1	/ reaction
ENSG00000172936	MYD88 / Q99836 / myeloid differentiation primary response 88	/ reaction
ENSG00000157212	PAXIP1 / Q6ZW49 / PAX interacting protein 1	/ complex / reaction
ENSG00000198001	IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4	/ complex / reaction
ENSG00000169139	Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2	/ complex
ENSG00000163322	Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit	/ complex / reaction
ENSG00000196419	XRCC6 / P12956 / X-ray repair cross complementing 6	/ reaction
ENSG00000152457	Q96SD1 / DCLRE1C / DNA cross-link repair 1C	/ complex / reaction
ENSG00000135341	MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7	/ complex
ENSG00000168148	Q16695 / HIST3H3 / histone cluster 3 H3	/ complex / reaction
ENSG00000055208	TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2	/ complex
ENSG00000066135	KDM4A / O75164 / lysine demethylase 4A	/ complex / reaction
ENSG00000188486	H2AFX / P16104 / H2A histone family member X	/ complex / reaction
ENSG00000137337	MDC1 / Q14676 / mediator of DNA damage checkpoint 1	/ complex / reaction
ENSG00000079246	XRCC5 / P13010 / X-ray repair cross complementing 5	/ reaction
ENSG00000087206	UIMC1 / Q96RL1 / ubiquitin interaction motif containing 1	/ complex / reaction
ENSG00000113522	RAD50 / Q92878 / RAD50 double strand break repair protein	/ complex / reaction
ENSG00000276180	P62805 / HIST1H4I / histone cluster 1 H4 family member i	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr