ENSG00000187608


Homo sapiens

Features
Gene ID: ENSG00000187608
  
Biological name :ISG15
  
Synonyms : ISG15 / ISG15 ubiquitin-like modifier / P05161
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.33
Gene start: 1001138
Gene end: 1014541
  
Corresponding Affymetrix probe sets: 205483_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368699
Ensembl peptide - ENSP00000485643
Ensembl peptide - ENSP00000485313
NCBI entrez gene - 9636     See in Manteia.
OMIM - 147571
RefSeq - NM_005101
RefSeq Peptide - NP_005092
swissprot - A0A096LPJ4
swissprot - A0A096LNZ9
swissprot - P05161
Ensembl - ENSG00000187608
  
Related genetic diseases (OMIM): 616126 - Immunodeficiency 38, 616126
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isg15ENSDARG00000086374Danio rerio
 Isg15ENSMUSG00000035692Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBC / P0CG48 / ubiquitin CENSG0000015099121
UBB / P0CG47 / ubiquitin BENSG0000017031519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR019956  Ubiquitin
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019941 modification-dependent protein catabolic process IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0032020 ISG15-protein conjugation IMP
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0032649 regulation of interferon-gamma production IMP
 biological_processGO:0034340 response to type I interferon IDA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060337 type I interferon signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031386 protein tag IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Interferon alpha/beta signaling
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0002721 Immunodeficiency 
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 HP:0011274 Recurrent mycobacterial infections "Increased susceptibility to mycobacterial infections, as manifested by recurrent episodes of mycobacterial infection." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000101751 POLI / Q9UNA4 / DNA polymerase iota  / reaction
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / reaction
 ENSG00000135945 REV1 / Q9UBZ9 / REV1, DNA directed polymerase  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / complex / reaction
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction / complex
 ENSG00000170142 P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1  / complex / reaction
 ENSG00000154914 USP43 / Q70EL4 / ubiquitin specific peptidase 43  / complex / reaction
 ENSG00000136068 FLNB / O75369 / filamin B  / complex / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / complex / reaction
 ENSG00000138032 PPM1B / O75688 / protein phosphatase, Mg2+/Mn2+ dependent 1B  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction
 ENSG00000069869 NEDD4 / P46934 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000170734 POLH / Q9Y253 / DNA polymerase eta  / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / reaction
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / complex / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / complex / reaction






 

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