ENSG00000161960


Homo sapiens

Features
Gene ID: ENSG00000161960
  
Biological name :EIF4A1
  
Synonyms : EIF4A1 / eukaryotic translation initiation factor 4A1 / P60842
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7572706
Gene end: 7579005
  
Corresponding Affymetrix probe sets: 201530_x_at (Human Genome U133 Plus 2.0 Array)   211787_s_at (Human Genome U133 Plus 2.0 Array)   214805_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462372
Ensembl peptide - ENSP00000462581
Ensembl peptide - ENSP00000462719
Ensembl peptide - ENSP00000462741
Ensembl peptide - ENSP00000462753
Ensembl peptide - ENSP00000462904
Ensembl peptide - ENSP00000463067
Ensembl peptide - ENSP00000463309
Ensembl peptide - ENSP00000463366
Ensembl peptide - ENSP00000463380
Ensembl peptide - ENSP00000463486
Ensembl peptide - ENSP00000463634
Ensembl peptide - ENSP00000463821
Ensembl peptide - ENSP00000464082
Ensembl peptide - ENSP00000464320
Ensembl peptide - ENSP00000464550
Ensembl peptide - ENSP00000293831
Ensembl peptide - ENSP00000461921
Ensembl peptide - ENSP00000462275
Ensembl peptide - ENSP00000464066
NCBI entrez gene - 1973     See in Manteia.
OMIM - 602641
RefSeq - NM_001204510
RefSeq - NM_001416
RefSeq Peptide - NP_001191439
RefSeq Peptide - NP_001407
swissprot - P60842
swissprot - J3KRC2
swissprot - J3KS25
swissprot - J3KS93
swissprot - J3KSP3
swissprot - J3KSZ0
swissprot - J3KT04
swissprot - J3KT12
swissprot - J3KTB5
swissprot - J3KTN0
swissprot - J3QKZ9
swissprot - J3QL43
swissprot - J3QL52
swissprot - J3QLN6
swissprot - J3QQP0
swissprot - J3QR64
swissprot - J3QRP5
swissprot - J3QS69
Ensembl - ENSG00000161960
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4a1aENSDARG00000092115Danio rerio
 eif4a1bENSDARG00000003032Danio rerio
 Eif4a1ENSMUSG00000059796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2ENSG0000015697690
EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3ENSG0000014154367


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037583  Eukaryotic initiation factor 4A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0016032 viral process IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000339 RNA cap binding TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003729 mRNA binding TAS
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / reaction
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / complex
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / complex
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / complex
 ENSG00000106682 EIF4H / Q15056 / eukaryotic translation initiation factor 4H  / complex
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / complex / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / complex
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / reaction
 ENSG00000125977 EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta  / reaction
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / complex
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction






 

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