Manteia

ENSG00000121060

Homo sapiens

Features

Gene ID:	ENSG00000121060

Biological name :	TRIM25

Synonyms :	Q14258 / TRIM25 / tripartite motif containing 25

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	17
Strand:	-1
Band:	q22
Gene start:	56887909
Gene end:	56914038

Corresponding Affymetrix probe sets:	206911_at (Human Genome U133 Plus 2.0 Array) 224806_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000459980 Ensembl peptide - ENSP00000323889 Ensembl peptide - ENSP00000445961 NCBI entrez gene - 7706 See in Manteia. OMIM - 600453 RefSeq - NM_005082 RefSeq Peptide - NP_005073 swissprot - I3L2W4 swissprot - Q14258 Ensembl - ENSG00000121060

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
trim25	ENSDARG00000104396	Danio rerio
TRIM25	ENSGALG00000003144	Gallus gallus
Q61510	ENSMUSG00000000275	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q96LD4 / TRIM47 / tripartite motif containing 47	ENSG00000132481	24
O95361 / TRIM16 / tripartite motif containing 16	ENSG00000221926	20
Q6PJ69 / TRIM65 / tripartite motif containing 65	ENSG00000141569	19
AC005324.3	ENSG00000251537	17
Q14134 / TRIM29 / tripartite motif containing 29	ENSG00000137699	16
Q309B1 / TRIM16L / tripartite motif containing 16 like	ENSG00000108448	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR000315	B-box-type zinc finger
IPR001841	Zinc finger, RING-type
IPR001870	B30.2/SPRY domain
IPR003877	SPRY domain
IPR003879	Butyrophylin-like, SPRY domain
IPR006574	SPRY-associated
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
IPR017907	Zinc finger, RING-type, conserved site
IPR027370	RING-type zinc-finger, LisH dimerisation motif

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP
biological_process	GO:0006513	protein monoubiquitination	IMP
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016567	protein ubiquitination	IEA
biological_process	GO:0016579	protein deubiquitination	TAS
biological_process	GO:0019985	translesion synthesis	TAS
biological_process	GO:0030433	ubiquitin-dependent ERAD pathway	IEA
biological_process	GO:0032480	negative regulation of type I interferon production	TAS
biological_process	GO:0033280	response to vitamin D	IEA
biological_process	GO:0036503	ERAD pathway	IMP
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA
biological_process	GO:0043627	response to estrogen	IDA
biological_process	GO:0045087	innate immune response	TAS
biological_process	GO:0046596	regulation of viral entry into host cell	IDA
biological_process	GO:0046597	negative regulation of viral entry into host cell	IEA
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP
biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP
biological_process	GO:0051607	defense response to virus	IEA
biological_process	GO:0060333	interferon-gamma-mediated signaling pathway	TAS
biological_process	GO:1902186	regulation of viral release from host cell	IMP
biological_process	GO:1902187	negative regulation of viral release from host cell	IEA
biological_process	GO:1990830	cellular response to leukemia inhibitory factor	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0016604	nuclear body	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	TAS
molecular_function	GO:0003723	RNA binding	HDA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	EXP
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016874	ligase activity	IEA
molecular_function	GO:0045296	cadherin binding	IDA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

ISG15 antiviral mechanism

DDX58/IFIH1-mediated induction of interferon-alpha/beta

Termination of translesion DNA synthesis

Ovarian tumor domain proteases

Interferon gamma signaling

TRAF3-dependent IRF activation pathway

TRAF6 mediated IRF7 activation

TRAF6 mediated NF-kB activation

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

Negative regulators of DDX58/IFIH1 signaling

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000068308	OTUD5 / Q96G74 / OTU deubiquitinase 5	/ reaction
ENSG00000106399	RPA3 / P35244 / replication protein A3	/ complex / reaction
ENSG00000101751	POLI / Q9UNA4 / DNA polymerase iota	/ complex / reaction
ENSG00000122008	POLK / Q9UBT6 / DNA polymerase kappa	/ complex / reaction
ENSG00000127191	TRAF2 / Q12933 / TNF receptor associated factor 2	/ complex / reaction
ENSG00000064012	CASP8 / Q14790 / caspase 8	/ complex / reaction
ENSG00000136560	TANK / Q92844 / TRAF family member associated NFKB activator	/ complex / reaction
ENSG00000135945	REV1 / Q9UBZ9 / REV1, DNA directed polymerase	/ complex / reaction
ENSG00000132383	RPA1 / P27694 / replication protein A1	/ complex / reaction
ENSG00000140853	NLRC5 / Q86WI3 / NLR family CARD domain containing 5	/ complex / reaction
ENSG00000003400	CASP10 / Q92851 / caspase 10	/ complex / reaction
ENSG00000156587	O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6	/ complex
ENSG00000117748	RPA2 / P15927 / replication protein A2	/ complex / reaction
ENSG00000183735	TBK1 / Q9UHD2 / TANK binding kinase 1	/ complex / reaction
ENSG00000052723	SIKE1 / Q9BRV8 / suppressor of IKBKE 1	/ reaction
ENSG00000137275	RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1	/ complex / reaction
ENSG00000078747	ITCH / Q96J02 / itchy E3 ubiquitin protein ligase	/ complex / reaction
ENSG00000168040	FADD / Q13158 / Fas associated via death domain	/ complex / reaction
ENSG00000126456	IRF3 / Q14653 / interferon regulatory factor 3	/ complex / reaction
ENSG00000104365	IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta	/ complex / reaction
ENSG00000181481	Q8IUD6 / RNF135 / ring finger protein 135	/ complex / reaction
ENSG00000182179	UBA7 / P41226 / ubiquitin like modifier activating enzyme 7	/ reaction
ENSG00000121060	Q14258 / TRIM25 / tripartite motif containing 25	/ complex / reaction
ENSG00000057663	ATG5 / Q9H1Y0 / autophagy related 5	/ complex / reaction
ENSG00000185507	IRF7 / Q92985 / interferon regulatory factor 7	/ complex / reaction
ENSG00000131323	TRAF3 / Q13114 / TNF receptor associated factor 3	/ complex / reaction
ENSG00000213341	CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase	/ complex / reaction
ENSG00000145782	ATG12 / O94817 / autophagy related 12	/ complex / reaction
ENSG00000187608	ISG15 / P05161 / ISG15 ubiquitin-like modifier	/ reaction
ENSG00000088888	MAVS / Q7Z434 / mitochondrial antiviral signaling protein	/ complex / reaction
ENSG00000269335	IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma	/ complex / reaction
ENSG00000263528	IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon	/ reaction / complex
ENSG00000197111	PCBP2 / Q15366 / poly(rC) binding protein 2	/ complex / reaction
ENSG00000175104	TRAF6 / Q9Y4K3 / TNF receptor associated factor 6	/ complex / reaction
ENSG00000170734	POLH / Q9Y253 / DNA polymerase eta	/ complex / reaction
ENSG00000107201	DDX58 / O95786 / DExD/H-box helicase 58	/ complex / reaction
ENSG00000132646	PCNA / P12004 / proliferating cell nuclear antigen	/ complex / reaction
ENSG00000095015	MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr