ENSG00000127191


Homo sapiens

Features
Gene ID: ENSG00000127191
  
Biological name :TRAF2
  
Synonyms : Q12933 / TNF receptor associated factor 2 / TRAF2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.3
Gene start: 136881912
Gene end: 136926607
  
Corresponding Affymetrix probe sets: 204413_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000247668
Ensembl peptide - ENSP00000406524
Ensembl peptide - ENSP00000405860
Ensembl peptide - ENSP00000397653
NCBI entrez gene - 7186     See in Manteia.
OMIM - 601895
RefSeq - XM_017015095
RefSeq - XM_011518974
RefSeq - XM_011518975
RefSeq - XM_011518976
RefSeq - XM_011518977
RefSeq - XM_011518978
RefSeq - XM_017015094
RefSeq - NM_021138
RefSeq - XM_011518973
RefSeq Peptide - NP_066961
swissprot - B1AMY1
swissprot - B1AMX8
swissprot - B1AMX7
swissprot - A0A024R8H5
swissprot - Q12933
Ensembl - ENSG00000127191
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf2aENSDARG00000030173Danio rerio
 unm_sa808ENSDARG00000078378Danio rerio
 TRAF2ENSGALG00000042838Gallus gallus
 Traf2ENSMUSG00000026942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRAF5 / O00463 / TNF receptor associated factor 5ENSG0000008251235
TRAF3 / Q13114 / TNF receptor associated factor 3ENSG0000013132335
TRAF1 / Q13077 / TNF receptor associated factor 1ENSG0000005655832
TRAF4 / Q9BUZ4 / TNF receptor associated factor 4ENSG0000007660427
TRAF6 / Q9Y4K3 / TNF receptor associated factor 6ENSG0000017510426


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027133  TNF receptor-associated factor 2
 IPR032070  TNF receptor-associated factor, BIRC3 binding domain
 IPR037305  TNF receptor-associated factor 2, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002726 positive regulation of T cell cytokine production IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0034622 cellular protein-containing complex assembly ISS
 biological_processGO:0034976 response to endoplasmic reticulum stress NAS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IDA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0051023 regulation of immunoglobulin secretion IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0060544 regulation of necroptotic process TAS
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
 biological_processGO:0070207 protein homotrimerization IPI
 biological_processGO:0070534 protein K63-linked ubiquitination IDA
 biological_processGO:0071550 death-inducing signaling complex assembly TAS
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0090073 positive regulation of protein homodimerization activity IMP
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway TAS
 biological_processGO:0097300 programmed necrotic cell death IEA
 biological_processGO:1901215 negative regulation of neuron death TAS
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:1903721 positive regulation of I-kappaB phosphorylation IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IPI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISS
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0035631 CD40 receptor complex ISS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097057 TRAF2-GSTP1 complex IDA
 cellular_componentGO:1990597 AIP1-IRE1 complex IEA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity NAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005174 CD40 receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031996 thioesterase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046625 sphingolipid binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
Dimerization of procaspase-8
TNF signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex / reaction
 ENSG00000052723 SIKE1 / Q9BRV8 / suppressor of IKBKE 1  / reaction
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / complex / reaction
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / complex / reaction
 ENSG00000120659 O14788 / TNFSF11 / TNF superfamily member 11  / complex / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / complex / reaction
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex / reaction
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000114316 USP4 / Q13107 / ubiquitin specific peptidase 4  / complex / reaction
 ENSG00000090686 USP48 / Q86UV5 / ubiquitin specific peptidase 48  / complex
 ENSG00000003402 CFLAR / O15519 / CASP8 and FADD like apoptosis regulator  / complex / reaction
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / complex / reaction
 ENSG00000141655 Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11a  / complex / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / reaction / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / complex / reaction
 ENSG00000101017 CD40 / P25942 / CD40 molecule  / complex / reaction
 ENSG00000102245 CD40LG / P29965 / CD40 ligand  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / complex / reaction
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / complex / reaction
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / complex / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / reaction / complex
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / complex / reaction
 ENSG00000159958 Q96RJ3 / TNFRSF13C / TNF receptor superfamily member 13C  / complex / reaction
 ENSG00000239697 O43508 / TNFSF12 / TNF superfamily member 12  / complex / reaction
 ENSG00000083799 CYLD / Q9NQC7 / CYLD lysine 63 deubiquitinase  / complex
 ENSG00000006327 Q9NP84 / TNFRSF12A / TNF receptor superfamily member 12A  / complex / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / complex / reaction
 ENSG00000102871 TRADD / Q15628 / TNFRSF1A associated via death domain  / complex / reaction
 ENSG00000102524 Q9Y275 / TNFSF13B / TNF superfamily member 13b  / complex / reaction
 ENSG00000028137 P20333 / TNFRSF1B / TNF receptor superfamily member 1B  / complex / reaction
 ENSG00000095015 MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1  / complex / reaction






 

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