ENSG00000006062


Homo sapiens

Features
Gene ID: ENSG00000006062
  
Biological name :MAP3K14
  
Synonyms : MAP3K14 / mitogen-activated protein kinase kinase kinase 14 / Q99558
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 45263121
Gene end: 45317040
  
Corresponding Affymetrix probe sets: 205192_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480974
Ensembl peptide - ENSP00000482657
Ensembl peptide - ENSP00000478552
NCBI entrez gene - 9020     See in Manteia.
OMIM - 604655
RefSeq - NM_003954
RefSeq - XM_011525441
RefSeq Peptide - NP_003945
swissprot - A0A087WXF1
swissprot - Q99558
Ensembl - ENSG00000006062
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arf2bENSDARG00000056582Danio rerio
 map3k14aENSDARG00000074060Danio rerio
 MAP3K14ENSGALG00000000685Gallus gallus
 Q9WUL6ENSMUSG00000020941Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP3K2 / Q9Y2U5 / mitogen-activated protein kinase kinase kinase 2ENSG0000016996715
Q56UN5 / MAP3K19 / mitogen-activated protein kinase kinase kinase 19ENSG0000017660115
MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1ENSG0000009501514
MAP3K3 / Q99759 / mitogen-activated protein kinase kinase kinase 3ENSG0000019890913
MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8ENSG0000010796812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017425  Mitogen-activated protein (MAP) kinase kinase kinase 14
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
Dectin-1 mediated noncanonical NF-kB signaling
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex / reaction
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex / reaction
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / complex / reaction
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / reaction
 ENSG00000159958 Q96RJ3 / TNFRSF13C / TNF receptor superfamily member 13C  / complex / reaction
 ENSG00000239697 O43508 / TNFSF12 / TNF superfamily member 12  / complex / reaction
 ENSG00000006327 Q9NP84 / TNFRSF12A / TNF receptor superfamily member 12A  / complex / reaction
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / complex / reaction
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / complex / reaction
 ENSG00000120659 O14788 / TNFSF11 / TNF superfamily member 11  / complex / reaction
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / complex / reaction
 ENSG00000141655 Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11a  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000101017 CD40 / P25942 / CD40 molecule  / complex / reaction
 ENSG00000102245 CD40LG / P29965 / CD40 ligand  / complex / reaction
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / complex / reaction
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction
 ENSG00000102524 Q9Y275 / TNFSF13B / TNF superfamily member 13b  / complex / reaction
 ENSG00000028137 P20333 / TNFRSF1B / TNF receptor superfamily member 1B  / complex / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / complex / reaction






 

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