ENSG00000110330


Homo sapiens

Features
Gene ID: ENSG00000110330
  
Biological name :BIRC2
  
Synonyms : baculoviral IAP repeat containing 2 / BIRC2 / Q13490
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q22.2
Gene start: 102347211
Gene end: 102378670
  
Corresponding Affymetrix probe sets: 202076_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432410
Ensembl peptide - ENSP00000484838
Ensembl peptide - ENSP00000477613
Ensembl peptide - ENSP00000436741
Ensembl peptide - ENSP00000434979
Ensembl peptide - ENSP00000434708
Ensembl peptide - ENSP00000434557
Ensembl peptide - ENSP00000433851
Ensembl peptide - ENSP00000227758
Ensembl peptide - ENSP00000431723
NCBI entrez gene - 329     See in Manteia.
OMIM - 601712
RefSeq - NM_001256163
RefSeq - NM_001256166
RefSeq - NM_001166
RefSeq Peptide - NP_001157
RefSeq Peptide - NP_001243092
RefSeq Peptide - NP_001243095
swissprot - E9PQZ9
swissprot - Q13490
swissprot - E9PNM6
swissprot - E9PMH5
swissprot - E9PIW1
swissprot - E9PI77
swissprot - A0A087X2B2
swissprot - H0YDY3
Ensembl - ENSG00000110330
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 birc2ENSDARG00000044619Danio rerio
 BIRC2ENSGALG00000017186Gallus gallus
 Birc2ENSMUSG00000057367Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BIRC3 / Q13489 / baculoviral IAP repeat containing 3ENSG0000002344571
XIAP / P98170 / X-linked inhibitor of apoptosisENSG0000010196631
NAIP / Q13075 / NLR family apoptosis inhibitory proteinENSG0000024943724
BIRC7 / Q96CA5 / baculoviral IAP repeat containing 7ENSG0000010119718
BIRC8 / Q96P09 / baculoviral IAP repeat containing 8ENSG0000016309816
NLRC4 / Q9NPP4 / NLR family CARD domain containing 4ENSG0000009110611


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001370  BIR repeat
 IPR001841  Zinc finger, RING-type
 IPR011029  Death-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0034121 regulation of toll-like receptor signaling pathway TAS
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0039535 regulation of RIG-I signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation TAS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0045088 regulation of innate immune response TAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045595 regulation of cell differentiation TAS
 biological_processGO:0050727 regulation of inflammatory response TAS
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0060544 regulation of necroptotic process TAS
 biological_processGO:0060546 negative regulation of necroptotic process IEA
 biological_processGO:0070266 necroptotic process IEA
 biological_processGO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0097194 execution phase of apoptosis TAS
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process IEA
 biological_processGO:1902523 positive regulation of protein K63-linked ubiquitination IDA
 biological_processGO:1902524 positive regulation of protein K48-linked ubiquitination IDA
 biological_processGO:1902527 positive regulation of protein monoubiquitination IDA
 biological_processGO:1902916 positive regulation of protein polyubiquitination IEA
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 biological_processGO:2000116 regulation of cysteine-type endopeptidase activity TAS
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0001741 XY body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0035631 CD40 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0003713 transcription coactivator activity IMP
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016740 transferase activity EXP
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0098770 FBXO family protein binding IPI


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / complex / reaction
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / complex / reaction
 ENSG00000120659 O14788 / TNFSF11 / TNF superfamily member 11  / complex / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex / reaction
 ENSG00000172046 USP19 / O94966 / ubiquitin specific peptidase 19  / complex / reaction
 ENSG00000141655 Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11a  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000102871 TRADD / Q15628 / TNFRSF1A associated via death domain  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / complex / reaction
 ENSG00000101017 CD40 / P25942 / CD40 molecule  / complex / reaction
 ENSG00000102245 CD40LG / P29965 / CD40 ligand  / complex / reaction
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / complex / reaction
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / complex / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / complex / reaction
 ENSG00000131508 P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2  / complex
 ENSG00000159958 Q96RJ3 / TNFRSF13C / TNF receptor superfamily member 13C  / complex / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000239697 O43508 / TNFSF12 / TNF superfamily member 12  / complex / reaction
 ENSG00000006327 Q9NP84 / TNFRSF12A / TNF receptor superfamily member 12A  / complex / reaction
 ENSG00000109332 P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3  / complex
 ENSG00000072401 P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1  / complex
 ENSG00000102524 Q9Y275 / TNFSF13B / TNF superfamily member 13b  / complex / reaction
 ENSG00000028137 P20333 / TNFRSF1B / TNF receptor superfamily member 1B  / complex / reaction






 

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