MP:0000291 | enlarged pericardium | "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6
|
MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB
|
MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB
|
MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL
|
MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6
|
MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Nr2e1frc/Nr2e1frc Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1Rbr/Birc3tm1Rbr Genetic Background: involves: BALB/cJ * C57BL/6
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr Genetic Background: involves: C57BL/6 * SJL
|
MP:0003105 | abnormal heart atrium morphology | "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6
|
MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB
|
MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Irs4tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * BALB/c
|
MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6
|
MP:0005244 | hemopericardium | "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6
|
MP:0005348 | increased T cell proliferation | "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Wdr35yeti/Wdr35yeti Genetic Background: Not Specified
|
MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6
|
MP:0008173 | increased follicular B cell number | "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB
|
MP:0008178 | decreased germinal center B cell number | "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB
|
MP:0008181 | increased marginal zone B cell number | "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB
|
MP:0008484 | decreased spleen germinal center size | "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB
|
MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
Show
Allelic Composition: Wdr35yeti/Wdr35yeti Genetic Background: Not Specified
|
MP:0008783 | decreased B cell apoptosis | "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB
|
MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx Genetic Background: involves: BALB/cJ * C57BL/6 * SJL
|
MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL
|
MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
Show
Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr Genetic Background: involves: 129S1/Sv * BALB/cJ * C57BL/6
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Tnfrsf1btm1Imx/Tnfrsf1btm1Imx Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk1tm1Led/Ripk1tm1Led Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL
|
MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3tm1Vmd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL
Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk1tm1Led/Ripk1+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
|