Manteia - Molecule gene

ENSMUSG00000028599

Mus musculus

Features

Gene ID:	ENSMUSG00000028599

Biological name :	Tnfrsf1b

Synonyms :	P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b

Possible biological names infered from orthology :	P20333 / TNF receptor superfamily member 1B

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	E1
Gene start:	145213463
Gene end:	145246870

Corresponding Affymetrix probe sets:	10518300 (MoGene1.0st) 1418099_at (Mouse Genome 430 2.0 Array) 1448951_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000115702 Ensembl peptide - ENSMUSP00000030336 NCBI entrez gene - 21938 See in Manteia. MGI - MGI:1314883 RefSeq - NM_011610 RefSeq Peptide - NP_035740 swissprot - D6RG55 swissprot - P25119 swissprot - Q545P4 Ensembl - ENSMUSG00000028599

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tnfrsf1b	ENSDARG00000070165	Danio rerio
TNFRSF1B	ENSGALG00000034213	Gallus gallus
P20333	ENSG00000028137	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9EPU5 / Tnfrsf21 / Tumor necrosis factor receptor superfamily member 21 / O75509* / TNF receptor superfamily member 21*	ENSMUSG00000023915	20
O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*	ENSMUSG00000026321	19
Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*	ENSMUSG00000030339	19
O08712 / Tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) / O00300* / TNF receptor superfamily member 11b*	ENSMUSG00000063727	19
Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*	ENSMUSG00000017652	13
Tnfrsf14 / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) / Q92956* / TNF receptor superfamily member 14*	ENSMUSG00000042333	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR001368	TNFR/NGFR cysteine-rich region
IPR020411	Tumour necrosis factor receptor 1B
IPR033996	Tumor necrosis factor receptor 1B, N-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006954	inflammatory response	IMP
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0007166	cell surface receptor signaling pathway	IMP
biological_process	GO:0007275	multicellular organism development	IBA
biological_process	GO:0007568	aging	IEA
biological_process	GO:0008283	cell proliferation	TAS
biological_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP
biological_process	GO:0032496	response to lipopolysaccharide	IEA
biological_process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IEA
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA
biological_process	GO:0050728	negative regulation of inflammatory response	IMP
biological_process	GO:0050779	RNA destabilization	IMP
biological_process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	IEA
biological_process	GO:0071222	cellular response to lipopolysaccharide	IEA
biological_process	GO:0071363	cellular response to growth factor stimulus	IEA
biological_process	GO:0097191	extrinsic apoptotic signaling pathway	IMP
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IDA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030424	axon	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0043196	varicosity	IEA
cellular_component	GO:0045121	membrane raft	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0005031	tumor necrosis factor-activated receptor activity	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0031625	ubiquitin protein ligase binding	IEA

Pathways (from Reactome)

Pathway description

TNFR2 non-canonical NF-kB pathway

TNFs bind their physiological receptors

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000003	abnormal adipose tissue morphology	"structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^W-82J/Kit⁺ Genetic Background: involves: C3HeB/FeLe
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn Genetic Background: involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tg(Gfap-TNF)K21Gkl/0,Tnfrsf1a^tm1Blt/Tnfrsf1a⁺ Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Tcf7^{tm1a(EUCOMM)Wtsi}/Tcf7^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Tcf7^{tm1a(EUCOMM)Wtsi}/Ics
MP:0001501	abnormal sleep pattern	"deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: B6.129P2-Tnfrsf1a^tm1Blt
MP:0001777	abnormal body temperature regulation	"anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eln^tm1Dyl/Eln⁺ Genetic Background: B6.129-Eln^tm1Dyl
MP:0001846	increased inflammatory response	"greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Fas^lpr/Fas^lpr,Tnfrsf1a^tm1Gkl/Tnfrsf1a^tm1Gkl Genetic Background: involves: 129/Sv * C57BL/6
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0001876	decreased inflammatory response	"less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002051	skin papilloma	"a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002329	abnormal blood gas	"anomaly in the amount of oxygen and carbon dioxide in the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scn1b^tm1.1Bion/Scn1b⁺ Genetic Background: Not Specified
MP:0002333	abnormal lung compliance	"anomalous pulmonary volume change per unit pressure change " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Scn1b^tm1.1Bion/Scn1b⁺ Genetic Background: Not Specified
MP:0002343	abnormal lymph node cortex	"anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ifngr1^tm1Agt/Ifngr1^tm1Agt Genetic Background: involves: 129S7/SvEvBrd * DBA/1OlaHsd Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0002345	abnormal lymph node primary follicle	"anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ifngr1^tm1Agt/Ifngr1^tm1Agt Genetic Background: involves: 129S7/SvEvBrd * DBA/1OlaHsd Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0002346	abnormal lymph node secondary follicle	"anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Ifngr1^tm1Agt/Ifngr1^tm1Agt Genetic Background: involves: 129S7/SvEvBrd * DBA/1OlaHsd Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0002411	decreased susceptibility to bacterial infection	"reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eln^tm1Dyl/Eln⁺ Genetic Background: B6.129-Eln^tm1Dyl Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-82J/Kit⁺ Genetic Background: involves: C3HeB/FeLe
MP:0002843	decreased blood pressure	"decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scn1b^tm1.1Bion/Scn1b⁺ Genetic Background: Not Specified
MP:0002886	abnormal glutamate receptor currents	"change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0002999	abnormal bone healing	"defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003037	increased infarction size	"increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003306	small intestinal inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Tnf^tm2Gkl/Tnf^tm2Gkl,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0003436	resistance to induced arthritis	"less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003561	rheumatoid arthritis	"an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tnf^tm2Gkl/Tnf⁺,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003690	abnormal glial cell physiology	"anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	"greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0004803	increased susceptibility to autoimmune diabetes	"greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fas^lpr/Fas^lpr,Tg(INS-Il10)#Sar/0 Genetic Background: NOD.Cg-Fas^lpr Tg(INS-Il10)#Sar
MP:0004804	decreased susceptibility to autoimmune diabetes	"reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prf1^tm1Clrk/Prf1^tm1Clrk,Tg(INS-Il10)#Sar/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * NOD
MP:0004811	abnormal neuron physiology	"anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004822	decreased susceptibility to experimental autoimmune uveoretinitis	"reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004992	increased bone resorption	"greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tcf7^{tm1a(EUCOMM)Wtsi}/Tcf7^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Tcf7^{tm1a(EUCOMM)Wtsi}/Ics
MP:0005027	increased susceptibility to parasitic infection	"greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0005048	thrombosis	"formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lhx1^tm2.1Bhr/Lhx1^tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0005190	osteomyelitis	"bone inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005266	abnormal metabolism	"anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^W-82J/Kit⁺ Genetic Background: involves: C3HeB/FeLe
MP:0005399	increased susceptibility to fungal infection	"greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005554	decreased circulating creatinine level	"less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Tcf7^{tm1a(EUCOMM)Wtsi}/Tcf7^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Tcf7^{tm1a(EUCOMM)Wtsi}/Ics
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Fas^lpr/Fas^lpr,Tg(INS-Il10)#Sar/0 Genetic Background: NOD.Cg-Fas^lpr Tg(INS-Il10)#Sar
MP:0005580	periinsulitis	"early pancreatic infiltration of mononuclear cells around pancreatic Langerhans islets" [J:11442, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Prf1^tm1Clrk/Prf1^tm1Clrk,Tg(INS-Il10)#Sar/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * NOD
MP:0006050	pulmonary fibrosis	"formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006060	increased cerebral infarction size	"increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006082	CNS inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]	Show Allelic Composition: Tg(Gfap-TNF)K21Gkl/0,Tnfrsf1a^tm1Blt/Tnfrsf1a⁺ Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008135	small Peyer s patches	"reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0008235	increased susceptibility to neuronal excitotoxicity	"greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008474	absent spleen germinal center	"absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0008523	absent lymph node germinal center	"absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Lhx1^tm2.1Bhr/Lhx1^tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0008688	decreased interleukin-2 secretion	"reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Lhx1^tm2.1Bhr/Lhx1^tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0008734	decreased susceptibility to endotoxin shock	"less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv
MP:0009764	decreased sensitivity to induced morbidity/mortality	"increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Tcf7^{tm1a(EUCOMM)Wtsi}/Tcf7^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Tcf7^{tm1a(EUCOMM)Wtsi}/Ics
MP:0010097	abnormal retinal blood vessel morphology	"any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0010205	abnormal oligodendrocyte apoptosis	"change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Gfap-TNF)K21Gkl/0,Tnfrsf1a^tm1Blt/Tnfrsf1a⁺ Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Birc2^tm1.1Rbr/Birc2^tm1.1Rbr,Birc3^tm1.1Rbr/Birc3^tm1.1Rbr,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Krt8^tm1Rgo/Krt8^tm1Rgo,Tnf^tm1Gkl/Tnf^tm1Gkl Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * FVB/N
MP:0011452	decreased susceptibility to dopaminergic neuron neurotoxicity	"less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0013239	impaired skeletal muscle regeneration	"reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0013251	dental pulp necrosis	"morphological changes resulting from pathological death of dental pulp tissue; usually due to irreversible damage" [MGI:csmith]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0020449	decreased microglial cell activation	"decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0030012	impaired central nervous system regeneration	"reduced or delayed ability to regenerate healthy central nervous system tissue following injury or disease" [MGI:anna]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: B6.129P2-Tnfrsf1a^tm1Blt

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024401	Tnf / P06804 / tumor necrosis factor / P01375*	/ complex / reaction
ENSMUSG00000021277	Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*	/ complex / reaction
ENSMUSG00000020941	Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*	/ complex / reaction
ENSMUSG00000024402	Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*	/ complex / reaction
ENSMUSG00000028599	P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*	/ complex / reaction
ENSMUSG00000026942	Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*	/ complex / reaction
ENSMUSG00000057367	Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*	/ complex / reaction

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