ENSMUSG00000042333


Mus musculus

Features
Gene ID: ENSMUSG00000042333
  
Biological name :Tnfrsf14
  
Synonyms : Tnfrsf14 / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
  
Possible biological names infered from orthology : Q92956 / TNF receptor superfamily member 14
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 154921933
Gene end: 154928563
  
Corresponding Affymetrix probe sets: 10519060 (MoGene1.0st)   1452425_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151979
Ensembl peptide - ENSMUSP00000117890
Ensembl peptide - ENSMUSP00000151279
Ensembl peptide - ENSMUSP00000151575
Ensembl peptide - ENSMUSP00000116757
NCBI entrez gene - 230979     See in Manteia.
MGI - MGI:2675303
RefSeq - XM_011250244
RefSeq - NM_178931
RefSeq - XM_006538830
RefSeq - XM_006538831
RefSeq - XM_006538832
RefSeq - XM_006538833
RefSeq Peptide - NP_849262
swissprot - Q80WM9
swissprot - A0A1W2P889
swissprot - F6Y2U8
swissprot - A0A1W2P7D5
swissprot - A0A1W2P6M8
Ensembl - ENSMUSG00000042333
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT737125.1ENSDARG00000068991Danio rerio
 si:ch211-261n11.7ENSDARG00000068966Danio rerio
 si:ch211-261n11.8ENSDARG00000089901Danio rerio
 si:dkey-23c22.5ENSDARG00000092892Danio rerio
 si:dkey-23c22.7ENSDARG00000095193Danio rerio
 zgc:153631ENSDARG00000068993Danio rerio
 zgc:153759ENSDARG00000092381Danio rerio
 zgc:153759ENSDARG00000068969Danio rerio
 Q92956ENSG00000157873Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*ENSMUSG0000002632124
Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*ENSMUSG0000003033924
Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*ENSMUSG0000001765223
Q9EPU5 / Tnfrsf21 / Tumor necrosis factor receptor superfamily member 21 / O75509* / TNF receptor superfamily member 21*ENSMUSG0000002391523
P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*ENSMUSG0000002859923
O08712 / Tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) / O00300* / TNF receptor superfamily member 11b*ENSMUSG0000006372722


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR022332  Tumour necrosis factor receptor 14
 IPR034031  Tumor necrosis factor receptor 14/UL144, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IMP
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046642 negative regulation of alpha-beta T cell proliferation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:2000406 positive regulation of T cell migration IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
Costimulation by the CD28 family
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001993 abnormal blinking 
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Commd10Tg(Vav1-icre)A2Kio/?,Tnfrsf14tm1.1Kro/Tnfrsf14tm1.1Kro
Genetic Background: involves: C57BL/6NCrl * C57BL/10 * CBA * SJL

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Commd10Tg(Vav1-icre)A2Kio/?,Tnfrsf14tm1.1Kro/Tnfrsf14tm1.1Kro
Genetic Background: involves: C57BL/6NCrl * C57BL/10 * CBA * SJL

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004752 decreased length of allograft survival "compared to controls, a reduced length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oca2p/Oca2p-8FDFoD
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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