ENSMUSG00000031132


Mus musculus

Features
Gene ID: ENSMUSG00000031132
  
Biological name :Cd40lg
  
Synonyms : Cd40lg / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P27548
  
Possible biological names infered from orthology : CD40 ligand / P29965
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A6
Gene start: 57212143
Gene end: 57224042
  
Corresponding Affymetrix probe sets: 10599802 (MoGene1.0st)   1422283_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033466
NCBI entrez gene - 21947     See in Manteia.
MGI - MGI:88337
RefSeq - NM_011616
RefSeq Peptide - NP_035746
swissprot - P27548
swissprot - Q0VEI3
Ensembl - ENSMUSG00000031132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD40LGENSGALG00000006415Gallus gallus
 CD40LGENSG00000102245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003263  CD40 ligand
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030183 B cell differentiation IGI
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0042100 B cell proliferation IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045190 isotype switching IDA
 biological_processGO:0048305 immunoglobulin secretion IGI
 biological_processGO:0051023 regulation of immunoglobulin secretion IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005174 CD40 receptor binding ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nogtm1Amc/Nogtm1Amc,Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * 129S1/Sv

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgm1Btlr/Cd40lgm1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chattm1Mlt/Chattm1Mlt,Tg(SLC18A3-cre)KMisa/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd40lgtm1Parl/Y,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Cd40lgtm1Parl/Y,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd40lgtm1Parl/Y,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0002491 decreased IgD "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Cd40lgtm1Parl/Y,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd40lgtm1Flv/Cd40lgtm1Flv
Genetic Background: NOD.Cg-Cd40lgtm1Flv Cd28tm1Mak

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd40lgm1Btlr/Cd40lgm1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd40lgtm1Flv/Cd40lgtm1Flv
Genetic Background: NOD.Cg-Cd40lgtm1Flv Cd28tm1Mak

 MP:0005002 abnormal T cell clonal deletion "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5tm1Cgn
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0005364 increased susceptibility to prion infection "increased likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd40lgtm1Parl/Y,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgtm1Parl/Y,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7ash1-6J/Myo7ash1-6J
Genetic Background: involves: C57BLKS/J

Allelic Composition: Cd40lgtm1Parl/Y,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Cd40lgtm1Parl/Y,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

Allelic Composition: Cd40lgtm1Imx/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010962 decreased compact bone mass 
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017652 Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex / reaction
 ENSMUSG00000031132 Cd40lg / P27548 / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P29965* / CD40 ligand*  / complex
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr