ENSGALG00000006415


Gallus gallus

Features
Gene ID: ENSGALG00000006415
  
Biological name :CD40LG
  
Synonyms : CD40LG / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / Q9I8D8
  
Possible biological names infered from orthology : CD40 ligand / P27548 / P29965
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 4393007
Gene end: 4397055
  
Corresponding Affymetrix probe sets: Gga.3027.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010340
Ensembl peptide - ENSGALP00000056186
NCBI entrez gene - 395485     See in Manteia.
RefSeq - NM_204733
RefSeq Peptide - NP_990064
swissprot - B6RCP9
swissprot - A0A1D5PTE1
swissprot - Q9I8D8
Ensembl - ENSGALG00000006415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD40LGENSG00000102245Homo sapiens
 Cd40lgENSMUSG00000031132Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003263  CD40 ligand
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0042100 B cell proliferation IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0048305 immunoglobulin secretion IEA
 biological_processGO:0051023 regulation of immunoglobulin secretion IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005174 CD40 receptor binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006415 CD40LG / Q9I8D8 / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P27548* / P29965* / CD40 ligand*  / complex
 ENSGALG00000011389 TRAF3 / TNF receptor associated factor 3 / Q13114* / Q60803*  / complex / reaction
 ENSGALG00000017186 BIRC2 / BIRC3* / Q62210* / Q13489* / Q13490* / baculoviral IAP repeat containing 2* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex / reaction
 ENSGALG00000007015 CD40 / tumor necrosis factor receptor superfamily member 5 precursor / P25942* / P27512* / CD40 molecule* / Tumor necrosis factor receptor superfamily member 5 *  / complex / reaction






 

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