ENSMUSG00000022015


Mus musculus

Features
Gene ID: ENSMUSG00000022015
  
Biological name :Tnfsf11
  
Synonyms : O35235 / Tnfsf11 / tumor necrosis factor (ligand) superfamily, member 11
  
Possible biological names infered from orthology : O14788 / TNF superfamily member 11
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D3
Gene start: 78277445
Gene end: 78308043
  
Corresponding Affymetrix probe sets: 10421737 (MoGene1.0st)   1419083_at (Mouse Genome 430 2.0 Array)   1451944_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022592
NCBI entrez gene - 21943     See in Manteia.
MGI - MGI:1100089
RefSeq - NM_011613
RefSeq Peptide - NP_035743
swissprot - O35235
Ensembl - ENSMUSG00000022015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfsf11ENSDARG00000068141Danio rerio
 TNFSF11ENSGALG00000026163Gallus gallus
 O14788ENSG00000120659Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P50592 / Tnfsf10 / tumor necrosis factor (ligand) superfamily, member 10 / P50591* / TNF superfamily member 10*ENSMUSG0000003930421


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR017355  Tumour necrosis factor ligand 10/11


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IMP
 biological_processGO:0002158 osteoclast proliferation IDA
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019722 calcium-mediated signaling IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IGI
 biological_processGO:0033598 mammary gland epithelial cell proliferation IMP
 biological_processGO:0034112 positive regulation of homotypic cell-cell adhesion IEA
 biological_processGO:0038001 paracrine signaling IDA
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0044691 tooth eruption IMP
 biological_processGO:0045453 bone resorption IDA
 biological_processGO:0045670 regulation of osteoclast differentiation IDA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045780 positive regulation of bone resorption IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IGI
 biological_processGO:0048535 lymph node development TAS
 biological_processGO:0050870 positive regulation of T cell activation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051466 positive regulation of corticotropin-releasing hormone secretion IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0055074 calcium ion homeostasis IGI
 biological_processGO:0060348 bone development IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion IDA
 biological_processGO:0071847 TNFSF11-mediated signaling pathway IEA
 biological_processGO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2001206 positive regulation of osteoclast development IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IPI


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Col10a1-cre)1427Vdm/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Col10a1-cre)1427Vdm/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000119 abnormal tooth eruption "anomalies in the passage of a tooth through the alveolar process and perforation of the gums" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * CD-1

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stam2Gt(pKC199)1Gaj/Stam2Gt(pKC199)1Gaj
Genetic Background: B6NCrl.Cg-Stam2Gt(pKC199)1Gaj

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(TNFSF11)5516Edou/0,Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002351 abnormal cervical lymph node morphology "anomalous structure, development, or number of the lymph nodes found near the neck and shoulders" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002835 abnormal cranial suture morphology "defects of the fibrous joint in the bones of the head" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62161]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004983 abnormal osteoclast cell number "deviation from the average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * CD-1

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tg(TNFSF11)5516Edou/0,Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008162 increased diameter of tibia "increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

 MP:0008464 absent peripheral lymph nodes "absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Ywc/Tnfsf11+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008465 absent mesenteric lymph nodes "absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0009544 abnormal thymus epithelium morphology "any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Ltbrtm1Mmat/Ltbrtm1Mmat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ltbrtm1Mmat/Ltbrtm1Mmat,Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0009633 absent cervical lymph nodes "absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0009917 abnormal hyoid bone body morphology "any structural anomaly of the main curve of the hyoid bone, from which the horns extend" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

Allelic Composition: Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * FVB/NJ

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob,Tg(Col10a1-cre)1427Vdm/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0011999 abnormal tail length "any anomaly in the length of tail relative to average of a given reference population" [MGI:csmith]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0012426 decreased skeletal tumor incidence "less than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0013614 abnormal areal bone mineral density "anomaly of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0013617 increased areal bone mineral density "increase in the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0013619 abnormal long bone internal diameter "anomaly of the cross-sectional distance that extends from one lateral edge of a long bone marrow cavity, through its center and to the opposite lateral edge of the bone marrow cavity through the mid point of the bone" [PMID:23197339]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0013621 decreased internal diameter of femur "reduced cross-sectional distance that extends from one lateral edge of the femur long bone marrow cavity, through its center and to the opposite lateral edge of the bone marrow cavity through the mid point of the femur" [PMID:23197339]
Show

Allelic Composition: Tnfsf11gum/Tnfsf11gum
Genetic Background: STOCK Tnfsf11gum/GrsrJ

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0030072 round face "facial appearance is more circular than usual as viewed from the front" [HP:0000311]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030279 thin neurocranium "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna]
Show

Allelic Composition: Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030469 optic canal stenosis "abnormal narrowing or constriction of the short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the ophthalmic artery" [MGI:anna]
Show

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / complex / reaction
 ENSMUSG00000022015 O35235 / Tnfsf11 / tumor necrosis factor (ligand) superfamily, member 11 / O14788* / TNF superfamily member 11*  / complex
 ENSMUSG00000063727 O08712 / Tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) / O00300* / TNF receptor superfamily member 11b*  / complex / reaction
 ENSMUSG00000026321 O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr