ENSGALG00000026163


Gallus gallus

Features
Gene ID: ENSGALG00000026163
  
Biological name :TNFSF11
  
Synonyms : TNFSF11 / tumor necrosis factor ligand superfamily member 11
  
Possible biological names infered from orthology : O14788 / O35235 / TNF superfamily member 11
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 166506011
Gene end: 166525895
  
Corresponding Affymetrix probe sets: GgaAffx.10863.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000040713
NCBI entrez gene - 428067     See in Manteia.
RefSeq - NM_001083361
RefSeq Peptide - NP_001076830
swissprot - R4GFC6
Ensembl - ENSGALG00000026163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfsf11ENSDARG00000068141Danio rerio
 O14788ENSG00000120659Homo sapiens
 O35235ENSMUSG00000022015Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNFSF10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*ENSGALG0000000917917
TRAIL-LIKEENSGALG0000000724015


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0002158 osteoclast proliferation IEA
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0034112 positive regulation of homotypic cell-cell adhesion IEA
 biological_processGO:0038001 paracrine signaling IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0044691 tooth eruption IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045780 positive regulation of bone resorption IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050870 positive regulation of T cell activation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051466 positive regulation of corticotropin-releasing hormone secretion IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055074 calcium ion homeostasis IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion IEA
 biological_processGO:0071847 TNFSF11-mediated signaling pathway IEA
 biological_processGO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2001206 positive regulation of osteoclast development IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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