ENSMUSG00000019927


Mus musculus

Features
Gene ID: ENSMUSG00000019927
  
Biological name :Ube2d1
  
Synonyms : P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1
  
Possible biological names infered from orthology : P51668
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B5.3
Gene start: 71254980
Gene end: 71285262
  
Corresponding Affymetrix probe sets: 10369877 (MoGene1.0st)   1424062_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020085
NCBI entrez gene - 216080     See in Manteia.
MGI - MGI:2384911
RefSeq - XM_006513478
RefSeq - NM_145420
RefSeq Peptide - NP_663395
swissprot - P61080
swissprot - Q3UFQ4
Ensembl - ENSMUSG00000019927
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2d1bENSDARG00000038576Danio rerio
 UBE2D1ENSGALG00000021213Gallus gallus
 P51668ENSG00000072401Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*ENSMUSG0000009189689
Q6ZWY6 / Ube2d2b / ubiquitin-conjugating enzyme E2D 2BENSMUSG0000006344784
P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*ENSMUSG0000007857884
Ube2dnl2 / ubiquitin-conjugating enzyme E2D N-terminal like 2ENSMUSG0000004707976
Ube2dnl1ENSMUSG0000005043574
P52482 / Ube2e1 / ubiquitin-conjugating enzyme E2E 1 / P51965*ENSMUSG0000002177461
P52483 / Ube2e3 / ubiquitin-conjugating enzyme E2E 3 / Q969T4*ENSMUSG0000002701161
Q91W82 / Ube2e2 / ubiquitin-conjugating enzyme E2E 2 / Q96LR5*ENSMUSG0000005831761
P68037 / Ube2l3 / ubiquitin-conjugating enzyme E2L 3ENSMUSG0000003896539
Ube2s / Q921J4 / ubiquitin-conjugating enzyme E2S / Q16763*ENSMUSG0000006086037
Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*ENSMUSG0000002707832


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:1902916 positive regulation of protein polyubiquitination IGI
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020283 Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*  / complex / reaction
 ENSMUSG00000020003 Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*  / complex / reaction
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex / reaction
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / reaction
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / reaction
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000024767 Otub1 / Q7TQI3 / Ubiquitin thioesterase OTUB1 / Q96FW1* / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction
 ENSMUSG00000025239 Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*  / reaction
 ENSMUSG00000031987 Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*  / reaction
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / reaction
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / complex / reaction
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / complex / reaction
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / reaction
 ENSMUSG00000035105 Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / reaction
 ENSMUSG00000040374 Pex2 / peroxisomal biogenesis factor 2 / P28328*  / complex / reaction
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex
 ENSMUSG00000055850 Q9CY62 / Rnf181 / Mus musculus ring finger protein 181 (Rnf181), transcript variant 11, mRNA. / Q9P0P0* / ring finger protein 181*  / complex / reaction
 ENSMUSG00000029047 Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*  / complex / reaction
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / reaction






 

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