ENSMUSG00000020003


Mus musculus

Features
Gene ID: ENSMUSG00000020003
  
Biological name :Pex7
  
Synonyms : P97865 / Peroxisomal targeting signal 2 receptor / Pex7
  
Possible biological names infered from orthology : O00628 / peroxisomal biogenesis factor 7
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A3
Gene start: 19853900
Gene end: 19907689
  
Corresponding Affymetrix probe sets: 10368162 (MoGene1.0st)   1418988_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020182
Ensembl peptide - ENSMUSP00000132996
NCBI entrez gene - 18634     See in Manteia.
MGI - MGI:1321392
RefSeq - NM_001161825
RefSeq - NM_008822
RefSeq Peptide - NP_001155297
RefSeq Peptide - NP_032848
swissprot - P97865
swissprot - B7ZNK8
Ensembl - ENSMUSG00000020003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pex7ENSDARG00000042553Danio rerio
 PEX7ENSGALG00000013874Gallus gallus
 PEX7ENSG00000112357Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wdr17 / WD repeat domain 17 / Q8IZU2*ENSMUSG0000003937519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0006625 protein targeting to peroxisome IMP
 biological_processGO:0006635 fatty acid beta-oxidation IMP
 biological_processGO:0007031 peroxisome organization IEA
 biological_processGO:0008611 ether lipid biosynthetic process IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016558 protein import into peroxisome matrix IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005782 peroxisomal matrix IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005053 peroxisome matrix targeting signal-2 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
Show

Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0003236 abnormal lens capsule morphology "malformation in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005286 decreased saturated fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain contains only single carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008570 lipidosis "abnormal fat metabolism with increased accumulation of specific lipids in tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex7tm1Nbra/Pex7tm1Nbra
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002763 Pex6 / Q99LC9 / Peroxisome assembly factor 2 / Q13608* / peroxisomal biogenesis factor 6*  / complex / reaction
 ENSMUSG00000005907 Pex1 / Q5BL07 / Peroxisome biosis factor 1 / O43933* / peroxisomal biogenesis factor 1*  / complex / reaction
 ENSMUSG00000020283 Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*  / complex
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / complex / reaction
 ENSMUSG00000010651 Acaa1b / Q8VCH0 / acetyl-Coenzyme A acyltransferase 1B / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / complex / reaction
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / complex
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex
 ENSMUSG00000026664 Phyh / O35386 / phytanoyl-CoA hydroxylase / O14832* / phytanoyl-CoA 2-hydroxylase*  / complex / reaction
 ENSMUSG00000036138 Acaa1a / Q921H8 / acetyl-Coenzyme A acyltransferase 1A / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / complex / reaction
 ENSMUSG00000040374 Pex2 / peroxisomal biogenesis factor 2 / P28328*  / complex
 ENSMUSG00000030629 Q9DCH6 / Zfand6 / zinc finger, AN1-type domain 6 / Q6FIF0* / zinc finger AN1-type containing 6*  / complex / reaction
 ENSMUSG00000067825 Pex26 / Q8BGI5 / Peroxisome assembly protein 26 / Q7Z412* / peroxisomal biogenesis factor 26*  / complex / reaction
 ENSMUSG00000029047 Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*  / complex
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / complex / reaction
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr