ENSMUSG00000091896


Mus musculus

Features
Gene ID: ENSMUSG00000091896
  
Biological name :Ube2d2a
  
Synonyms : P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A
  
Possible biological names infered from orthology : P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B2
Gene start: 35771559
Gene end: 35807172
  
Corresponding Affymetrix probe sets: 10454842 (MoGene1.0st)   10498800 (MoGene1.0st)   1416475_at (Mouse Genome 430 2.0 Array)   1416476_a_at (Mouse Genome 430 2.0 Array)   1416477_at (Mouse Genome 430 2.0 Array)   1445885_at (Mouse Genome 430 2.0 Array)   1448356_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131206
Ensembl peptide - ENSMUSP00000132446
NCBI entrez gene - 56550     See in Manteia.
MGI - MGI:1930715
RefSeq - XM_006526120
RefSeq - NM_019912
RefSeq Peptide - NP_064296
swissprot - P62838
swissprot - Q3UT95
Ensembl - ENSMUSG00000091896
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2d2ENSDARG00000043484Danio rerio
 UBE2D2ENSGALG00000038128Gallus gallus
 P62837ENSG00000131508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZWY6 / Ube2d2b / ubiquitin-conjugating enzyme E2D 2BENSMUSG0000006344793
P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*ENSMUSG0000007857893
P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*ENSMUSG0000001992789
Ube2dnl2 / ubiquitin-conjugating enzyme E2D N-terminal like 2ENSMUSG0000004707978
Ube2dnl1ENSMUSG0000005043578
P52483 / Ube2e3 / ubiquitin-conjugating enzyme E2E 3 / Q969T4*ENSMUSG0000002701164
P52482 / Ube2e1 / ubiquitin-conjugating enzyme E2E 1 / P51965*ENSMUSG0000002177463
Q91W82 / Ube2e2 / ubiquitin-conjugating enzyme E2E 2 / Q96LR5*ENSMUSG0000005831763
P68037 / Ube2l3 / ubiquitin-conjugating enzyme E2L 3ENSMUSG0000003896539
Ube2s / Q921J4 / ubiquitin-conjugating enzyme E2S / Q16763*ENSMUSG0000006086038
Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*ENSMUSG0000002707833


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: involves: 101/H * C3H/HeH * STOCK MR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020283 Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*  / complex / reaction
 ENSMUSG00000020003 Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*  / complex / reaction
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex / reaction
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / reaction
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / reaction
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction
 ENSMUSG00000025239 Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*  / reaction
 ENSMUSG00000031987 Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*  / reaction
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / reaction
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / complex / reaction
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / complex / reaction
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / reaction
 ENSMUSG00000035105 Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / reaction
 ENSMUSG00000040374 Pex2 / peroxisomal biogenesis factor 2 / P28328*  / complex / reaction
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex
 ENSMUSG00000055850 Q9CY62 / Rnf181 / Mus musculus ring finger protein 181 (Rnf181), transcript variant 11, mRNA. / Q9P0P0* / ring finger protein 181*  / complex / reaction
 ENSMUSG00000029047 Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*  / complex / reaction
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / reaction






 

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