Manteia

ENSMUSG00000022400

Mus musculus

Features

Gene ID:	ENSMUSG00000022400

Biological name :	Rbx1

Synonyms :	E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62878 / Rbx1

Possible biological names infered from orthology :	P62877 / ring-box 1

Species:	Mus musculus

Chr. number:	15
Strand:	1
Band:	E1
Gene start:	81466296
Gene end:	81476369

Corresponding Affymetrix probe sets:	10425522 (MoGene1.0st) 10450646 (MoGene1.0st) 1416577_a_at (Mouse Genome 430 2.0 Array) 1416578_at (Mouse Genome 430 2.0 Array) 1438623_x_at (Mouse Genome 430 2.0 Array) 1440061_at (Mouse Genome 430 2.0 Array) 1447793_x_at (Mouse Genome 430 2.0 Array) 1448387_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000023036 Ensembl peptide - ENSMUSP00000154877 Ensembl peptide - ENSMUSP00000155288 NCBI entrez gene - 56438 See in Manteia. MGI - MGI:1891829 RefSeq - NM_019712 RefSeq Peptide - NP_062686 swissprot - P62878 Ensembl - ENSMUSG00000022400

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rbx1	ENSDARG00000038030	Danio rerio
RBX1	ENSGALG00000011993	Gallus gallus
RBX1	ENSG00000100387	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gm7075 / RNF7* / Q9UBF6* / ring finger protein 7*	ENSMUSG00000048185	46
Rnf7 / Q9WTZ1 / RING-box protein 2 / Q9UBF6* / ring finger protein 7*	ENSMUSG00000051234	46

Protein motifs (from Interpro)

Interpro ID	Name
IPR001841	Zinc finger, RING-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR024766	Zinc finger, RING-H2-type

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	TAS
biological_process	GO:0006513	protein monoubiquitination	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0016567	protein ubiquitination	ISS
biological_process	GO:0030163	protein catabolic process	IMP
biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0045116	protein neddylation	IEA
cellular_component	GO:0000151	ubiquitin ligase complex	TAS
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005680	anaphase-promoting complex	TAS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0019005	SCF ubiquitin ligase complex	IEA
cellular_component	GO:0030891	VCB complex	IEA
cellular_component	GO:0031461	cullin-RING ubiquitin ligase complex	IEA
cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	IEA
cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	IEA
cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	IEA
cellular_component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	IEA
cellular_component	GO:0031466	Cul5-RING ubiquitin ligase complex	IEA
cellular_component	GO:0031467	Cul7-RING ubiquitin ligase complex	IEA
cellular_component	GO:0043224	nuclear SCF ubiquitin ligase complex	IBA
cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	IBA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0008190	eukaryotic initiation factor 4E binding	TAS
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019788	NEDD8 transferase activity	IEA
molecular_function	GO:0031625	ubiquitin protein ligase binding	IEA
molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IEA
molecular_function	GO:0097602	cullin family protein binding	IEA

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pou4f2^tm1Nat/Pou4f2^tm1Nat Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Rbx1^Gt(XB674)Byg/Rbx1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Pou4f2^tm1Nat/Pou4f2^tm1Nat Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Rbx1^Gt(XB674)Byg/Rbx1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009781	abnormal preimplantation embryo development	"an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Nat/Pou4f2^tm1Nat Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Pou4f2^tm1Nat/Pou4f2^tm1Nat Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Rbx1^Gt(XB674)Byg/Rbx1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0013504	increased embryonic tissue cell apoptosis	"increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Pou4f2^tm1Nat/Pou4f2^tm1Nat Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000003233	Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*	/ complex / reaction
ENSMUSG00000005575	Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*	/ complex / reaction
ENSMUSG00000019927	P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*	/ reaction
ENSMUSG00000010376	Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*	/ complex / reaction
ENSMUSG00000020888	Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*	/ complex / reaction
ENSMUSG00000020114	Cand1 / Q6ZQ38 / Cullin-associated NEDD8-dissociated protein 1 / Q86VP6* / cullin associated and neddylation dissociated 1*	/ complex / reaction
ENSMUSG00000024140	Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*	/ complex / reaction
ENSMUSG00000026455	Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*	/ complex
ENSMUSG00000022812	Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*	/ complex / reaction
ENSMUSG00000024740	Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*	/ complex
ENSMUSG00000021109	Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*	/ complex / reaction
ENSMUSG00000024927	Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*	/ complex / reaction
ENSMUSG00000000751	Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*	/ complex / reaction
ENSMUSG00000005268	Prlr / Q08501 / prolactin receptor / P16471*	/ complex / reaction
ENSMUSG00000031446	Cul4a / Q3TCH7 / Cullin-4A / Q13619*	/ complex
ENSMUSG00000031095	Cul4b / A2A432 / Cullin-4B / Q13620*	/ complex
ENSMUSG00000012483	Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*	/ complex / reaction
ENSMUSG00000024789	Jak2 / Janus kinase 2 / O60674*	/ complex / reaction
ENSMUSG00000024231	Cul2 / Q9D4H8 / Cullin-2 / Q13617*	/ complex
ENSMUSG00000022400	Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*	/ complex
ENSMUSG00000024854	Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*	/ complex / reaction
ENSMUSG00000026496	Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*	/ complex / reaction
ENSMUSG00000031143	Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*	/ reaction / complex
ENSMUSG00000031987	Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*	/ complex
ENSMUSG00000029686	Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*	/ complex / reaction
ENSMUSG00000002109	Ddb2 / Q99J79 / DNA damage-binding protein 2 / Q92466* / damage specific DNA binding protein 2*	/ complex
ENSMUSG00000028329	Xpa / Q64267 / xeroderma pigmentosum, complementation group A / P23025* / XPA, DNA damage recognition and repair factor*	/ reaction / complex
ENSMUSG00000038037	Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*	/ complex
ENSMUSG00000004328	Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*	/ complex / reaction
ENSMUSG00000033933	Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*	/ complex
ENSMUSG00000028703	Lrrc41 / Q8K1C9 / Leucine-rich repeat-containing protein 41 / Q15345* / leucine rich repeat containing 41*	/ complex
ENSMUSG00000038545	Cul7 / Q8VE73 / Cullin-7 / Q14999*	/ complex / reaction
ENSMUSG00000036309	Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*	/ complex / reaction
ENSMUSG00000035105	Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*	/ complex
ENSMUSG00000028426	P54728 / Rad23b / UV excision repair B / P54727* / RAD23 homolog B, nucleotide excision repair protein*	/ complex / reaction
ENSMUSG00000031347	Cetn2 / Q9R1K9 / Centrin-2 / P41208*	/ complex / reaction
ENSMUSG00000030094	Xpc / P51612 / xeroderma pigmentosum, complementation group C / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*	/ complex / reaction
ENSMUSG00000027342	Pcna / P17918 / proliferating cell nuclear antigen / P12004*	/ complex / reaction
ENSMUSG00000055839	Elob / P62869 / Elongin-B / Q15370*	/ complex
ENSMUSG00000051355	Commd1 / Q8K4M5 / COMM domain-containing protein 1 / Q8N668* / copper metabolism domain containing 1*	/ reaction / complex
ENSMUSG00000038644	Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*	/ complex / reaction
ENSMUSG00000053113	Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*	/ complex
ENSMUSG00000025217	Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*	/ complex
ENSMUSG00000021694	Ercc8 / Q8CFD5 / DNA excision repair protein ERCC-8 / Q13216* / ERCC excision repair 8, CSA ubiquitin ligase complex subunit*	/ complex
ENSMUSG00000048787	Q8K0V2 / Dcun1d3 / DCN1-like protein 3 / Q8IWE4* / defective in cullin neddylation 1 domain containing 3*	/ complex / reaction
ENSMUSG00000048402	Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*	/ complex / reaction
ENSMUSG00000054051	Ercc6 / ERCC excision repair 6, chromatin remodeling factor / P0DP91* / Q03468* / Q8N328*	/ complex / reaction
ENSMUSG00000054115	Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*	/ complex
ENSMUSG00000041117	Ccdc8 / D3YZV8 / Coiled-coil domain-containing / Q9H0W5* / coiled-coil domain containing 8*	/ complex / reaction
ENSMUSG00000020471	Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*	/ complex / reaction
ENSMUSG00000020713	Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...	/ complex / reaction
ENSMUSG00000028884	Rpa2 / replication protein A2 / P15927*	/ complex / reaction
ENSMUSG00000026211	Obsl1 / D3YYU8 / Obscurin-like protein 1 / O75147* / obscurin like 1*	/ complex / reaction
ENSMUSG00000039153	Runx2 / Q08775 / runt related transcription factor 2 / Q13950*	/ complex / reaction
ENSMUSG00000079658	Eloc / P83940 / Elongin-C / Q15369*	/ complex
ENSMUSG00000021318	Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*	/ complex / reaction
ENSMUSG00000004364	Cul3 / Q9JLV5 / Cullin-3 / Q13618*	/ complex
ENSMUSG00000025917	Cops5 / O35864 / COP9 signalosome complex subunit 5 / Q92905* / COP9 signalosome subunit 5*	/ reaction
ENSMUSG00000037474	Dtl / Q3TLR7 / Denticleless protein homolog / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*	/ complex
ENSMUSG00000021025	Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*	/ complex / reaction
ENSMUSG00000025239	Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*	/ complex
ENSMUSG00000066640	Fbxl18 / F-box and leucine rich repeat protein 18 / Q96ME1*	/ complex
ENSMUSG00000027496	Aurka / P97477 / Aurora kinase A / O14965*	/ complex / reaction
ENSMUSG00000032030	Cul5 / cullin 5 / Q93034*	/ complex
ENSMUSG00000028086	Fbxw7 / Q8VBV4 / F-box/WD repeat-containing protein 7 / Q969H0* / F-box and WD repeat domain containing 7*	/ complex
ENSMUSG00000028163	Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*	/ complex / reaction
ENSMUSG00000028089	Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*	/ complex / reaction
ENSMUSG00000043881	Kbtbd7 / Q86V97* / Q8WVZ9* / KBTBD6* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*	/ complex
ENSMUSG00000040327	Cul9 / cullin 9 / Q8IWT3*	/ complex
ENSMUSG00000043556	Fbxl7 / Q5BJ29 / F-box/LRR-repeat protein 7 / Q9UJT9* / F-box and leucine rich repeat protein 7*	/ complex / reaction
ENSMUSG00000057522	Spop / Q6ZWS8 / Mus musculus speckle-type POZ protein (Spop), transcript variant 2, mRNA. / O43791* / speckle type BTB/POZ protein*	/ complex
ENSMUSG00000078578	P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*	/ reaction
ENSMUSG00000091896	P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr