ENSMUSG00000028329


Mus musculus

Features
Gene ID: ENSMUSG00000028329
  
Biological name :Xpa
  
Synonyms : Q64267 / xeroderma pigmentosum, complementation group A / Xpa
  
Possible biological names infered from orthology : P23025 / XPA, DNA damage recognition and repair factor
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 46155347
Gene end: 46196311
  
Corresponding Affymetrix probe sets: 10512739 (MoGene1.0st)   1437320_s_at (Mouse Genome 430 2.0 Array)   1456002_at (Mouse Genome 430 2.0 Array)   1460725_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030013
Ensembl peptide - ENSMUSP00000050453
Ensembl peptide - ENSMUSP00000121850
Ensembl peptide - ENSMUSP00000138512
NCBI entrez gene - 22590     See in Manteia.
MGI - MGI:99135
RefSeq - NM_011728
RefSeq Peptide - NP_035858
swissprot - Q64267
swissprot - Q8K2X7
swissprot - S4R260
Ensembl - ENSMUSG00000028329
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xpaENSDARG00000038114Danio rerio
 XPAENSGALG00000028998Gallus gallus
 XPAENSG00000136936Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000465  XPA
 IPR009061  Putative DNA-binding domain superfamily
 IPR022652  Zinc finger, XPA-type, conserved site
 IPR022656  XPA, C-terminal
 IPR022658  XPA, conserved site
 IPR037129  XPA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition IBA
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006289 nucleotide-excision repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0009650 UV protection ISO
 biological_processGO:0033683 nucleotide-excision repair, DNA incision IBA
 biological_processGO:0034504 protein localization to nucleus ISO
 biological_processGO:0035264 multicellular organism growth IGI
 biological_processGO:0070914 UV-damage excision repair IBA
 biological_processGO:1901255 nucleotide-excision repair involved in interstrand cross-link repair IBA
 cellular_componentGO:0000110 nucleotide-excision repair factor 1 complex IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005662 DNA replication factor A complex ISO
 cellular_componentGO:0045171 intercellular bridge ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd

 MP:0000548 long limbs "increased average length of the extremities" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc2tm3Jhjh/Ercc2tm3Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Ercc2tm3Jhjh/Ercc2tm3Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001272 increased metastatic potential 
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ercc2tm3Jhjh/Ercc2tm3Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Ercc2tm3Jhjh/Ercc2tm3Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc2tm3Jhjh/Ercc2tm3Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: LnpkUl/LnpkUl
Genetic Background: involves: C3H/HeJ * C57BL/6J * MOLF/Ei

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0002879 increased sensitivity to X-ray irradiation "increased incidence of cell death following high levels of X-ray irradiation" [RGD:Rat Genome Database submission]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Trp53tm1Tyj/Trp53+,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004501 increased incidence of UV-induced tumors "higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006099 thin granule layer "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Xpatm1Gvh/Xpatm1Hvs,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il5tm1Ktk/Il5+
Genetic Background: B6.129S4-Il5tm1Ktk

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc3tm2Jhjh/Ercc3tm2Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009387 abnormal epidermal pigmentation "anomaly in coloration of the epidermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009796 abnormal base-excision repair "any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase" [GO:0006284]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0010289 increased urinary system tumor incidence "greater than the expected number of tumors originating in the urinary system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Hrhr/Hrhr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ercc2tm3Jhjh/Ercc2tm3Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011174 lipodystrophy "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Hvs/Xpatm1Hvs
Genetic Background: B6.129P2-Xpatm1Hvs Ercc6tm1Gvh

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0013551 decreased cerebellar granule cell precursor proliferation "reduction in the ability of a cerebellar granule cell precursor population to undergo rapid expansion by cell division" [MGI:csmith]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0030003 hippocampus atrophy "acquired diminution of the size of the hippocampus associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal change" [MGI:anna]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Gvh/Xpatm1Hvs,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / reaction / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / reaction / complex
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / reaction / complex
 ENSMUSG00000002109 Ddb2 / Q99J79 / DNA damage-binding protein 2 / Q92466* / damage specific DNA binding protein 2*  / reaction / complex
 ENSMUSG00000028426 P54728 / Rad23b / UV excision repair B / P54727* / RAD23 homolog B, nucleotide excision repair protein*  / complex / reaction
 ENSMUSG00000031347 Cetn2 / Q9R1K9 / Centrin-2 / P41208*  / complex / reaction
 ENSMUSG00000030094 Xpc / P51612 / xeroderma pigmentosum, complementation group C / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / complex / reaction
 ENSMUSG00000028089 Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*  / complex / reaction






 

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