ENSMUSG00000038644


Mus musculus

Features
Gene ID: ENSMUSG00000038644
  
Biological name :Pold1
  
Synonyms : P52431 / Pold1 / polymerase (DNA directed), delta 1, catalytic subunit
  
Possible biological names infered from orthology : DNA polymerase delta 1, catalytic subunit / P28340
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44532746
Gene end: 44548849
  
Corresponding Affymetrix probe sets: 10562818 (MoGene1.0st)   1448187_at (Mouse Genome 430 2.0 Array)   1456055_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039776
Ensembl peptide - ENSMUSP00000117844
Ensembl peptide - ENSMUSP00000117157
NCBI entrez gene - 18971     See in Manteia.
MGI - MGI:97741
RefSeq - NM_011131
RefSeq Peptide - NP_035261
swissprot - D6RFB8
swissprot - D3YVY8
swissprot - P52431
Ensembl - ENSMUSG00000038644
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pold1ENSDARG00000027689Danio rerio
 POLD1ENSG00000062822Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006133  DNA-directed DNA polymerase, family B, exonuclease domain
 IPR006134  DNA-directed DNA polymerase, family B, multifunctional domain
 IPR006172  DNA-directed DNA polymerase, family B
 IPR012337  Ribonuclease H-like superfamily
 IPR017964  DNA-directed DNA polymerase, family B, conserved site
 IPR023211  DNA polymerase, palm domain superfamily
 IPR025687  C4-type zinc-finger of DNA polymerase delta
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000731 DNA synthesis involved in DNA repair ISO
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006287 base-excision repair, gap-filling ISO
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0034644 cellular response to UV ISO
 biological_processGO:0045004 DNA replication proofreading IMP
 biological_processGO:0055089 fatty acid homeostasis ISO
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000109 nucleotide-excision repair complex ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0043625 delta DNA polymerase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003684 damaged DNA binding ISS
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008296 3"-5"-exodeoxyribonuclease activity IBA
 molecular_functionGO:0008408 3"-5" exonuclease activity IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Pold1tm1.1Uchi/Pold1tm1.1Uchi
Genetic Background: C57BL/6-Pold1tm1.1Uchi

Allelic Composition: Pold1tm1Uchi/Pold1tm1.1Uchi
Genetic Background: C57BL/6-Pold1tm1Uchi/Pold1tm1.1Uchi

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pold1tm2Loeb/Pold1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pold1tm1.1Uchi/Pold1tm1.1Uchi
Genetic Background: C57BL/6-Pold1tm1.1Uchi

Allelic Composition: Pold1tm1Uchi/Pold1tm1.1Uchi
Genetic Background: C57BL/6-Pold1tm1Uchi/Pold1tm1.1Uchi

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: B6.129-Pold1tm1.1Bdp

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp,Poletm1.1Bdp/Poletm1.1Bdp
Genetic Background: B6.129-Poletm1.1Bdp Pold1tm1.1Bdp

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pold1tm1Loeb/Pold1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pold1tm2Loeb/Pold1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pold1tm1.1Uchi/Pold1tm1.1Uchi
Genetic Background: C57BL/6-Pold1tm1.1Uchi

Allelic Composition: Pold1tm1Uchi/Pold1tm1.1Uchi
Genetic Background: C57BL/6-Pold1tm1Uchi/Pold1tm1.1Uchi

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: B6.129-Pold1tm1.1Bdp

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp,Poletm1.1Bdp/Poletm1.1Bdp
Genetic Background: B6.129-Poletm1.1Bdp Pold1tm1.1Bdp

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: B6.129-Pold1tm1.1Bdp

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: B6.129-Pold1tm1.1Bdp

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: involves: 129 * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: involves: 129 * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Pold1tm1Loeb/Pold1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: B6.129-Pold1tm1.1Bdp

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: B6.129-Pold1tm1.1Bdp

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp,Poletm1.1Bdp/Poletm1.1Bdp
Genetic Background: B6.129-Poletm1.1Bdp Pold1tm1.1Bdp

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Msh2tm1Rak/Msh2tm1Rak,Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: involves: 129 * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Pold1tm1Loeb/Pold1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Krastm3Tyj/Krastm3Tyj
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak,Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni
Genetic Background: involves: 129 * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: B6.129-Pold1tm1.1Bdp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020390 Ube2b / P63147 / ubiquitin-conjugating enzyme E2B / P63146*  / complex / reaction
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / complex / reaction
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / complex / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex / reaction
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / reaction / complex
 ENSMUSG00000037474 Dtl / Q3TLR7 / Denticleless protein homolog / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex
 ENSMUSG00000030254 Rad18 / Q9QXK2 / RAD18 E3 ubiquitin protein ligase / Q9NS91*  / complex / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / complex / reaction
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / complex / reaction
 ENSMUSG00000031536 Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*  / reaction
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / reaction
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex / reaction
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000056394 Lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr