ENSMUSG00000036875
Mus musculus dna Dna2 activity replication binding telomere processing mitochondrial repair removal helicase strand homologous hydrolase checkpoint maintenance double-strand break damage regulation chromosome endonuclease cluster flap intermediate hdr pairing exchange increased incidence factor
Features Gene ID: ENSMUSG00000036875 Biological name :Dna2 Synonyms : Dna2 / / Possible biological names infered from orthology : DNA replication helicase/nuclease 2 / Species: Mus musculus Chr. number: 10 Strand: 1 Band: B4 Gene start: 62947026 Gene end: 62974185 Corresponding Affymetrix probe sets: 10363575 (MoGene1.0st) 1438817_at (Mouse Genome 430 2.0 Array) 1452210_at (Mouse Genome 430 2.0 Array) 1457909_at (Mouse Genome 430 2.0 Array) Cross references: Ensembl peptide - ENSMUSP00000090119327762
See in Manteia .
MGI:2443732 XM_017313971 NM_177372 NP_796346 Q6ZQJ5 ENSMUSG00000036875
See expression report in BioGPS See gene description in Wikigenes See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl )No match Protein motifs (from Interpro )Gene Ontology (GO ) cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cycle nitrogen compound metabolic process cellular component organization cellular metabolic process primary metabolic process regulation of biological quality organic substance metabolic process response to stress cellular response to stimulus biosynthetic process catabolic process cell cyclecell cycle nitrogen comnitrogen compound metabolic process cellular comcellular component organization cellular metcellular metabolic process primary metaprimary metabolic process regulation oregulation of biological quality organic subsorganic substance metabolic process response to response to stress cellular rescellular response to stimulus biosyntheticbiosynthetic process catabolic prcatabolic process organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on DNA hydrolase activity protein binding ion binding carbohydrate derivative binding drug binding metal cluster binding cofactor binding organic cyclorganic cyclic compound binding heterocyclicheterocyclic compound binding small molecusmall molecule binding catalytic accatalytic activity, acting on DNA hydrolase achydrolase activity protein bindprotein binding ion bindingion binding carbohydratecarbohydrate derivative binding drug bindingdrug binding metal clustemetal cluster binding cofactor bincofactor binding cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cell organelle membrane-enclosed lumen protein-containing complex nucleoid cellcell organelleorganelle membrane-enclosed lumenmembrane-enclosed lumen protein-containing complexprotein-containing complex nucleoidnucleoid
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesis respiratory system phenotype cellular phenotype liver/biliary system phenotype mortality/aging tumorigenesistumorigenesis respiratory system phenotyperespiratory system phenotype cellular phenotypecellular phenotype liver/biliary system phenotyliver/biliary system phenotype mortality/agingmortality/aging MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Pmp22Tr-2J /Pmp22+ Genetic Background: C57BL/6J-Pmp22Tr-2J /GrsrJ
Interacting proteins (from Reactome ) ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1* / complex / reaction ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha* / complex ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit* / complex / reaction ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated* / complex / reaction ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3* / complex / reaction ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3* / complex / reaction ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2* / complex / reaction ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit* / complex / reaction ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1* / complex / reaction ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit* / complex / reaction ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1* / complex / reaction ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934* / complex / reaction ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1* / complex ENSMUSG00000031583 Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191* / complex ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease* / complex / reaction ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2* / complex ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004* / complex / reaction ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease* / complex / reaction ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit* / complex / reaction ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase* / complex ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535* / complex / reaction ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1* / complex / reaction ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1* / complex / reaction ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5* / complex / reaction ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase* / complex / reaction ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit* / complex / reaction ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927* / complex / reaction
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