ENSDARG00000078759


Danio rerio

Features
Gene ID: ENSDARG00000078759
  
Biological name :dna2
  
Synonyms : dna2 / DNA replication helicase/nuclease 2
  
Possible biological names infered from orthology : DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530 / Q6ZQJ5
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 22821647
Gene end: 22839767
  
Corresponding Affymetrix probe sets: Dr.17469.1.A1_at (Zebrafish Array)   Dr.17469.2.S1_at (Zebrafish Array)   XM_682882_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000103307
Ensembl peptide - ENSDARP00000112574
NCBI entrez gene - 559535     See in Manteia.
RefSeq - XM_021480834
RefSeq - XM_682882
RefSeq - XM_021474283
swissprot - F1Q892
swissprot - B8A5D8
ZFIN ID - ZDB-GENE-090313-71
Ensembl - ENSDARG00000078759
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DNA2ENSGALG00000004037Gallus gallus
 DNA2ENSG00000138346Homo sapiens
 Dna2ENSMUSG00000036875Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR014808  DNA replication factor Dna2, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006264 mitochondrial DNA replication ISS
 biological_processGO:0006284 base-excision repair ISS
 biological_processGO:0033567 DNA replication, Okazaki fragment processing IEA
 biological_processGO:0043137 DNA replication, removal of RNA primer ISS
 biological_processGO:0045740 positive regulation of DNA replication ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005760 gamma DNA polymerase complex ISS
 molecular_functionGO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base ISS
 molecular_functionGO:0017108 5"-flap endonuclease activity IEA
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity IEA


Pathways (from Reactome)
Pathway description
Removal of the Flap Intermediate from the C-strand
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
Removal of the Flap Intermediate
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052721 prim2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / complex / reaction
 ENSDARG00000015070 pola2 / polymerase (DNA directed), alpha 2 / P33611* / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000063076 atrip / ATR interacting protein / Q8BMG1* / Q8WXE1*  / complex / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000052827 top3a / DNA topoisomerase III alpha / O70157* / Q13472* / topoisomerase (DNA) III alpha*  / complex
 ENSDARG00000103137 rmi2 / RecQ mediated genome instability 2 / Q3UPE3* / Q96E14* / RecQ-mediated genome instability protein 2 *  / complex
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000074410 brip1 / BRCA1 interacting protein C-terminal helicase 1 / Q5SXJ3* / Q9BX63* / Fanconi anemia group J protein homolog *  / complex / reaction
 ENSDARG00000045308 pola1 / polymerase (DNA directed), alpha 1 / P09884* / P33609* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSDARG00000098211 wrn / Werner syndrome / O09053* / Q14191* / Werner syndrome RecQ like helicase*  / complex






 

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