ENSDARG00000052721


Danio rerio

Features
Gene ID: ENSDARG00000052721
  
Biological name :prim2
  
Synonyms : DNA primase subunit 2 / prim2
  
Possible biological names infered from orthology : DNA primase large subunit / P33610 / P49643
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 23488282
Gene end: 23612369
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000012598
Ensembl peptide - ENSDARP00000120104
Ensembl peptide - ENSDARP00000115722
NCBI entrez gene - 407653     See in Manteia.
RefSeq - NM_214782
RefSeq - XM_005156811
RefSeq Peptide - NP_999947
swissprot - B8JIP3
swissprot - B8JIP2
ZFIN ID - ZDB-GENE-050522-471
Ensembl - ENSDARG00000052721
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRIM2ENSGALG00000016278Gallus gallus
 PRIM2ENSG00000146143Homo sapiens
 Prim2ENSMUSG00000026134Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007238  DNA primase large subunit, eukaryotic/archaeal
 IPR016558  DNA primase, large subunit, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006269 DNA replication, synthesis of RNA primer IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IBA
 molecular_functionGO:0003896 DNA primase activity IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052721 prim2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / reaction
 ENSDARG00000008551 pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / complex / reaction
 ENSDARG00000013016 pole4 / polymerase (DNA-directed), epsilon 4, accessory subunit / Q9CQ36* / Q9NR33* / DNA polymerase epsilon 4, accessory subunit* / polymerase (DNA-directed), epsilon 4 (p12 subunit)*  / complex / reaction
 ENSDARG00000015070 pola2 / polymerase (DNA directed), alpha 2 / P33611* / Q14181* / DNA polymerase alpha 2, accessory subunit*  / reaction / complex
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000058533 pole / polymerase (DNA directed), epsilon / Q07864* / Q9WVF7* / DNA polymerase epsilon, catalytic subunit*  / complex / reaction
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / complex / reaction
 ENSDARG00000045308 pola1 / polymerase (DNA directed), alpha 1 / P09884* / P33609* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction
 ENSDARG00000011404 fen1 / Q6TNU4 / flap structure-specific endonuclease 1 / P39748*  / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / complex / reaction






 

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