ENSDARG00000058533


Danio rerio

Features
Gene ID: ENSDARG00000058533
  
Biological name :pole
  
Synonyms : pole / polymerase (DNA directed), epsilon
  
Possible biological names infered from orthology : DNA polymerase epsilon, catalytic subunit / Q07864 / Q9WVF7
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 12743640
Gene end: 12804906
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000075852
NCBI entrez gene - 553405     See in Manteia.
RefSeq - NM_001128523
RefSeq Peptide - NP_001121995
swissprot - B0V351
ZFIN ID - ZDB-GENE-070705-557
Ensembl - ENSDARG00000058533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000007665Gallus gallus
 ENSGALG00000039384Gallus gallus
 POLEENSG00000177084Homo sapiens
 PoleENSMUSG00000007080Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006133  DNA-directed DNA polymerase, family B, exonuclease domain
 IPR006134  DNA-directed DNA polymerase, family B, multifunctional domain
 IPR006172  DNA-directed DNA polymerase, family B
 IPR012337  Ribonuclease H-like superfamily
 IPR013697  DNA polymerase epsilon, catalytic subunit A, C-terminal
 IPR023211  DNA polymerase, palm domain superfamily
 IPR029703  DNA polymerase epsilon catalytic subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IBA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006272 leading strand elongation IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006287 base-excision repair, gap-filling IBA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IBA
 biological_processGO:0045004 DNA replication proofreading IBA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0008622 epsilon DNA polymerase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008310 single-stranded DNA 3"-5" exodeoxyribonuclease activity IBA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Telomere C-strand synthesis initiation
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052721 prim2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / complex / reaction
 ENSDARG00000013016 pole4 / polymerase (DNA-directed), epsilon 4, accessory subunit / Q9CQ36* / Q9NR33* / DNA polymerase epsilon 4, accessory subunit* / polymerase (DNA-directed), epsilon 4 (p12 subunit)*  / complex
 ENSDARG00000015070 pola2 / polymerase (DNA directed), alpha 2 / P33611* / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSDARG00000008551 pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / complex
 ENSDARG00000045308 pola1 / polymerase (DNA directed), alpha 1 / P09884* / P33609* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr