ENSDARG00000043480


Danio rerio

Features
Gene ID: ENSDARG00000043480
  
Biological name :rbbp8
  
Synonyms : F1R983 / rbbp8 / retinoblastoma binding protein 8
  
Possible biological names infered from orthology : Q80YR6 / Q99708 / RB binding protein 8, endonuclease / retinoblastoma binding protein 8, endonuclease
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 36204028
Gene end: 36223943
  
Corresponding Affymetrix probe sets: Dr.21899.1.A1_at (Zebrafish Array)   NM_001012500_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000063831
Ensembl peptide - ENSDARP00000127552
NCBI entrez gene - 503536     See in Manteia.
RefSeq - NM_001012500
RefSeq Peptide - NP_001012518
swissprot - F1R983
swissprot - X1WBG1
ZFIN ID - ZDB-GENE-050220-14
Ensembl - ENSDARG00000043480
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RBBP8ENSGALG00000014982Gallus gallus
 RBBP8ENSG00000101773Homo sapiens
 Rbbp8ENSMUSG00000041238Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch211-200e2.1 / Q8NC74* / RBBP8NL* / RBBP8 N-terminal like*ENSDARG0000008703214


Protein motifs (from Interpro)
Interpro ID Name
 IPR013882  DNA endonuclease Ctp1, C-terminal
 IPR019518  DNA endonuclease Ctp1, N-terminal
 IPR033316  DNA endonuclease RBBP8-like
 IPR033594  DNA endonuclease RBBP8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSDARG00000009494 xrcc1 / X-ray repair complementing defective repair in Chinese hamster cells 1 / P18887* / Q60596* / X-ray repair cross complementing 1*  / complex / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000052553 lig3 / ligase III, DNA, ATP-dependent / P49916* / DNA ligase 3*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000011404 fen1 / Q6TNU4 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / complex / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex
 ENSDARG00000044622 polq / polymerase (DNA directed), theta / O75417* / Q8CGS6* / DNA polymerase theta*  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000063076 atrip / ATR interacting protein / Q8BMG1* / Q8WXE1*  / complex / reaction
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000052827 top3a / DNA topoisomerase III alpha / O70157* / Q13472* / topoisomerase (DNA) III alpha*  / complex / reaction
 ENSDARG00000098211 wrn / Werner syndrome / O09053* / Q14191* / Werner syndrome RecQ like helicase*  / complex / reaction
 ENSDARG00000103137 rmi2 / RecQ mediated genome instability 2 / Q3UPE3* / Q96E14* / RecQ-mediated genome instability protein 2 *  / complex / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000041411 rad51 / RAD51 recombinase / Q06609* / Q08297* / AC012476.1* / DNA repair 1 *  / complex
 ENSDARG00000074410 brip1 / BRCA1 interacting protein C-terminal helicase 1 / Q5SXJ3* / Q9BX63* / Fanconi anemia group J protein homolog *  / complex / reaction
 ENSDARG00000079015 brca2 / breast cancer 2, early onset / P97929* / P51587* / BRCA2, DNA repair associated* / Breast cancer type 2 susceptibility protein homolog *  / complex






 

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