ENSDARG00000052827


Danio rerio

Features
Gene ID: ENSDARG00000052827
  
Biological name :top3a
  
Synonyms : DNA topoisomerase III alpha / top3a
  
Possible biological names infered from orthology : O70157 / Q13472 / topoisomerase (DNA) III alpha
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 40235288
Gene end: 40254634
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000127896
NCBI entrez gene - 560212     See in Manteia.
RefSeq - XM_683603
swissprot - X1WCF3
ZFIN ID - ZDB-GENE-071212-2
Ensembl - ENSDARG00000052827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TOP3AENSGALG00000005028Gallus gallus
 TOP3AENSG00000177302Homo sapiens
 Top3aENSMUSG00000002814Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
top3b / DNA topoisomerase III beta / O95985* / Q9Z321* / topoisomerase (DNA) III beta*ENSDARG0000002758628


Protein motifs (from Interpro)
Interpro ID Name
 IPR003601  DNA topoisomerase, type IA, domain 2
 IPR003602  DNA topoisomerase, type IA, DNA-binding domain
 IPR006171  TOPRIM domain
 IPR010666  Zinc finger, GRF-type
 IPR013497  DNA topoisomerase, type IA, central
 IPR013498  DNA topoisomerase, type IA, zn finger
 IPR013825  DNA topoisomerase, type IA, central region, subdomain 2
 IPR023405  DNA topoisomerase, type IA, core domain
 IPR023406  DNA topoisomerase, type IA, active site
 IPR034144  DNA topoisomerase 3-like, TOPRIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006265 DNA topological change IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001078 thymus thymus decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
Show

 ZFA:0009046 T cell T cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSDARG00000063076 atrip / ATR interacting protein / Q8BMG1* / Q8WXE1*  / complex / reaction
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / complex
 ENSDARG00000074410 brip1 / BRCA1 interacting protein C-terminal helicase 1 / Q5SXJ3* / Q9BX63* / Fanconi anemia group J protein homolog *  / complex / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000103137 rmi2 / RecQ mediated genome instability 2 / Q3UPE3* / Q96E14* / RecQ-mediated genome instability protein 2 *  / complex
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction






 

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