ENSDARG00000079015


Danio rerio

Features
Gene ID: ENSDARG00000079015
  
Biological name :brca2
  
Synonyms : brca2 / breast cancer 2, early onset
  
Possible biological names infered from orthology : BRCA2, DNA repair associated / Breast cancer type 2 susceptibility protein homolog / P51587 / P97929
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 31911989
Gene end: 31928519
  
Corresponding Affymetrix probe sets: Dr.15884.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000099674
NCBI entrez gene - 566758     See in Manteia.
RefSeq - NM_001110394
RefSeq - XM_005157363
RefSeq Peptide - NP_001103864
swissprot - F1R8E8
ZFIN ID - ZDB-GENE-060510-3
Ensembl - ENSDARG00000079015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BRCA2ENSGALG00000017073Gallus gallus
 BRCA2ENSG00000139618Homo sapiens
 Brca2ENSMUSG00000041147Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002093  BRCA2 repeat
 IPR012340  Nucleic acid-binding, OB-fold
 IPR015187  BRCA2, OB1
 IPR015188  BRCA2, OB3
 IPR015205  Tower domain
 IPR015252  Breast cancer type 2 susceptibility protein, helical domain
 IPR015525  Breast cancer type 2 susceptibility protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007530 sex determination IMP
 biological_processGO:0008585 female gonad development IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000242 male organism male organism sterile , abnormal
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 ZFA:0000303 female organism female organism absent , abnormal
Show

 ZFA:0000403 ovary ovary absent , abnormal
ovary decreased amount , abnormal
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 ZFA:0000413 gonad gonad apoptotic chromosome condensation present , abnormal
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 ZFA:0000598 testis testis spermatid absent , abnormal
testis sperm absent , abnormal
testis hyperplastic , abnormal
testis has fewer parts of type spermatocyte , abnormal
testis neoplastic , abnormal
testis degeneration , abnormal
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 ZFA:0009005 spermatocyte spermatocyte apoptotic , abnormal
spermatocyte apoptotic chromosome condensation increased amount , abnormal
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 ZFA:0009133 Sertoli cell Sertoli cell disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000041411 rad51 / RAD51 recombinase / Q06609* / Q08297* / AC012476.1* / DNA repair 1 *  / complex
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex
 ENSDARG00000104765 chek1 / checkpoint kinase 1 / O14757* / O35280* / Serine/threonine-protein kinase Chk1 *  / reaction






 

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