ENSGALG00000017073


Gallus gallus

Features
Gene ID: ENSGALG00000017073
  
Biological name :BRCA2
  
Synonyms : BRCA2 / BRCA2, DNA repair associated
  
Possible biological names infered from orthology : Breast cancer type 2 susceptibility protein homolog / P51587 / P97929
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 174560560
Gene end: 174597292
  
Corresponding Affymetrix probe sets: Gga.1.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059403
Ensembl peptide - ENSGALP00000027524
NCBI entrez gene - 374139     See in Manteia.
RefSeq - XM_015277493
RefSeq - NM_204276
RefSeq Peptide - NP_989607
swissprot - A0A1L1RKW5
swissprot - F1P3B2
Ensembl - ENSGALG00000017073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brca2ENSDARG00000079015Danio rerio
 BRCA2ENSG00000139618Homo sapiens
 Brca2ENSMUSG00000041147Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002093  BRCA2 repeat
 IPR012340  Nucleic acid-binding, OB-fold
 IPR015187  BRCA2, OB1
 IPR015188  BRCA2, OB3
 IPR015205  Tower domain
 IPR015252  Breast cancer type 2 susceptibility protein, helical domain
 IPR015525  Breast cancer type 2 susceptibility protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051298 centrosome duplication IEA
 biological_processGO:0070200 establishment of protein localization to telomere IEA
 biological_processGO:1990426 mitotic recombination-dependent replication fork processing IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000800 lateral element IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0033593 BRCA2-MAGE-D1 complex IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0010484 H3 histone acetyltransferase activity IEA
 molecular_functionGO:0010485 H4 histone acetyltransferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex
 ENSGALG00000017290 RAD51AP1 / RAD51 associated protein 1 / Q96B01* / RAD51-associated protein 1 isoform 2 *  / complex
 ENSGALG00000030313 RAD51 / P37383 / DNA repair protein RAD51 homolog 1 / Q08297* / Q06609* / AC012476.1* / DNA repair 1 * / RAD51 recombinase*  / complex / reaction
 ENSGALG00000042418 CHEK1 / Q8AYC9 / Serine/threonine-protein kinase Chk1 / O14757* / O35280* / checkpoint kinase 1*  / reaction






 

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