ENSDARG00000104765


Danio rerio

Features
Gene ID: ENSDARG00000104765
  
Biological name :chek1
  
Synonyms : checkpoint kinase 1 / chek1
  
Possible biological names infered from orthology : O14757 / O35280 / Serine/threonine-protein kinase Chk1
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 22558187
Gene end: 22565170
  
Corresponding Affymetrix probe sets: Dr.15882.1.A1_at (Zebrafish Array)   NM_200193_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000133390
NCBI entrez gene - 393162     See in Manteia.
RefSeq - NM_200193
RefSeq Peptide - NP_956487
swissprot - Q7ZVD7
ZFIN ID - ZDB-GENE-040426-896
Ensembl - ENSDARG00000104765
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHEK1ENSGALG00000042418Gallus gallus
 CHEK1ENSG00000149554Homo sapiens
 Chek1ENSMUSG00000032113Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bsk146 / brain specific kinase 146ENSDARG0000009906921
unm_sa1261 / un-named sa1261ENSDARG0000003161820
si:dkey-8e10.3 / SBK2* / P0C5K1* / P0C263* / Serine/threonine-protein kinase SBK2 * / SH3 domain binding kinase family member 2*ENSDARG0000005894418
si:ch211-183d21.3 / SBK1* / Q8QZX0* / Q52WX2* / SH3 domain binding kinase 1* / Serine/threonine-protein kinase SBK1 *ENSDARG0000005629417
si:ch211-171h4.3ENSDARG0000002045515
sbk3 / SH3 domain binding kinase family, member 3ENSDARG0000005768715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IGI
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism apoptotic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010792 cdc25b / cell division cycle 25B / CDC25A* / P30305* / P30306* / P48964* / P30304* / cell division cycle 25A* / M-phase inducer phosphatase 1 * / M-phase inducer phosphatase 2 *  / reaction
 ENSDARG00000008119 si:ch211-195d17.2 / E2F6* / O54917* / O75461* / E2F transcription factor 6* / Transcription factor E2F6 *  / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000041411 rad51 / RAD51 recombinase / Q06609* / Q08297* / AC012476.1* / DNA repair 1 *  / reaction
 ENSDARG00000079015 brca2 / breast cancer 2, early onset / P97929* / P51587* / BRCA2, DNA repair associated* / Breast cancer type 2 susceptibility protein homolog *  / reaction






 

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