Manteia

ENSMUSG00000000751

Mus musculus

Features

Gene ID:	ENSMUSG00000000751

Biological name :	Rpa1

Synonyms :	Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / Rpa1

Possible biological names infered from orthology :	P27694 / replication protein A1

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	B5
Gene start:	75298166
Gene end:	75348324

Corresponding Affymetrix probe sets:	10388409 (MoGene1.0st) 1423293_at (Mouse Genome 430 2.0 Array) 1437309_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000000767 Ensembl peptide - ENSMUSP00000090585 NCBI entrez gene - 68275 See in Manteia. MGI - MGI:1915525 RefSeq - XM_006534051 RefSeq - NM_001164223 RefSeq - NM_026653 RefSeq Peptide - NP_080929 RefSeq Peptide - NP_001157695 swissprot - Q5SWN2 swissprot - Q8VEE4 Ensembl - ENSMUSG00000000751

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rpa1	ENSDARG00000003938	Danio rerio
RPA1	ENSGALG00000003072	Gallus gallus
RPA1	ENSG00000132383	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR004365	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR004591	Replication factor A protein 1
IPR007199	Replication factor-A protein 1, N-terminal
IPR012340	Nucleic acid-binding, OB-fold
IPR013955	Replication factor A, C-terminal
IPR031657	Replication protein A, OB domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000723	telomere maintenance	IEA
biological_process	GO:0000724	double-strand break repair via homologous recombination	IEA
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0006260	DNA replication	IEA
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006284	base-excision repair	IEA
biological_process	GO:0006289	nucleotide-excision repair	IEA
biological_process	GO:0006298	mismatch repair	IEA
biological_process	GO:0006310	DNA recombination	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IMP
biological_process	GO:0030097	hemopoiesis	IMP
biological_process	GO:0034502	protein localization to chromosome	IEA
biological_process	GO:0048873	homeostasis of number of cells within a tissue	IMP
biological_process	GO:0051276	chromosome organization	IMP
biological_process	GO:0051321	meiotic cell cycle	IDA
cellular_component	GO:0000793	condensed chromosome	IDA
cellular_component	GO:0000794	condensed nuclear chromosome	IDA
cellular_component	GO:0000800	lateral element	IDA
cellular_component	GO:0001673	male germ cell nucleus	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005662	DNA replication factor A complex	IEA
cellular_component	GO:0016605	PML body	IEA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003684	damaged DNA binding	IEA
molecular_function	GO:0003697	single-stranded DNA binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0098505	G-rich strand telomeric DNA binding	IEA

Pathways (from Reactome)

Pathway description

Translesion synthesis by REV1

Recognition of DNA damage by PCNA-containing replication complex

Translesion Synthesis by POLH

Removal of the Flap Intermediate from the C-strand

Activation of ATR in response to replication stress

SUMOylation of DNA damage response and repair proteins

Regulation of HSF1-mediated heat shock response

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

PCNA-Dependent Long Patch Base Excision Repair

Translesion synthesis by POLK

Translesion synthesis by POLI

Termination of translesion DNA synthesis

HDR through Single Strand Annealing (SSA)

HDR through Homologous Recombination (HRR)

Processing of DNA double-strand break ends

Formation of Incision Complex in GG-NER

Gap-filling DNA repair synthesis and ligation in GG-NER

Dual Incision in GG-NER

Dual incision in TC-NER

Gap-filling DNA repair synthesis and ligation in TC-NER

Fanconi Anemia Pathway

Regulation of TP53 Activity through Phosphorylation

Activation of the pre-replicative complex

Removal of the Flap Intermediate

G2/M DNA damage checkpoint

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptger2^tm1Sna/Ptger2^tm1Sna Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptger2^tm1Sna/Ptger2^tm1Sna Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptger2^tm1Sna/Ptger2^tm1Sna Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J
MP:0004028	chromosome breakage	"chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptger2^tm1Sna/Ptger2^tm1Sna Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptger2^tm1Sna/Ptger2^tm1Sna Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011094	complete embryonic lethality before implantation	"death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]	Show Allelic Composition: Ptger2^tm1Sna/Ptger2^tm1Sna Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Ptger2^tm1Sna/Ptger2^tm1Sna Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0013292	embryonic lethality prior to organogenesis	"death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]	Show Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000028	Cdc45 / Q9Z1X9 / Cell division control / O75419* / cell division cycle 45*	/ complex / reaction
ENSMUSG00000000275	Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*	/ complex / reaction
ENSMUSG00000002814	Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*	/ complex / reaction
ENSMUSG00000003549	Ercc1 / P07903 / DNA excision repair protein ERCC-1 / P07992* / ERCC excision repair 1, endonuclease non-catalytic subunit*	/ complex / reaction
ENSMUSG00000002297	A / Dbf4 / Q9QZ41 / Q9UBU7* / DBF4 zinc finger*	/ complex / reaction
ENSMUSG00000005262	Ufd1 / P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Q92890*	/ complex / reaction
ENSMUSG00000017146	Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*	/ complex / reaction
ENSMUSG00000020265	Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*	/ reaction
ENSMUSG00000020380	Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*	/ complex / reaction
ENSMUSG00000019841	Rev3l / Q61493 / DNA polymerase zeta catalytic subunit / O60673* / REV3 like, DNA directed polymerase zeta catalytic subunit*	/ complex / reaction
ENSMUSG00000020905	Usp43 / Q8BUM9 / ubiquitin specific peptidase 43 / Q70EL4*	/ complex / reaction
ENSMUSG00000026669	Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*	/ complex / reaction
ENSMUSG00000025358	Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*	/ complex / reaction
ENSMUSG00000021668	Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*	/ complex / reaction
ENSMUSG00000026048	Ercc5 / ERCC excision repair 5, endonuclease / P28715*	/ complex / reaction
ENSMUSG00000026082	Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*	/ complex / reaction
ENSMUSG00000022545	Ercc4 / Q9QZD4 / DNA repair endonuclease XPF / Q92889* / ERCC excision repair 4, endonuclease catalytic subunit*	/ complex / reaction
ENSMUSG00000026196	Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*	/ complex / reaction
ENSMUSG00000028224	Nbn / Q9R207 / Nibrin / O60934*	/ complex / reaction
ENSMUSG00000039703	Nploc4 / P60670 / Nuclear protein localization / Q8TAT6* / NPL4 homolog, ubiquitin recognition factor*	/ complex / reaction
ENSMUSG00000035367	Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*	/ complex / reaction
ENSMUSG00000031986	Sprtn / G3X912 / SprT-like domain-containing protein Spartan / Q9H040* / SprT-like N-terminal domain*	/ complex / reaction
ENSMUSG00000029003	Mad2l2 / Q9D752 / Mitotic spindle assembly checkpoint protein MAD2B / Q9UI95* / mitotic arrest deficient 2 like 2*	/ complex / reaction
ENSMUSG00000031583	Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*	/ complex / reaction
ENSMUSG00000031536	Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*	/ reaction
ENSMUSG00000032409	Atr / ATR serine/threonine kinase / Q13535*	/ complex / reaction
ENSMUSG00000039748	Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*	/ complex / reaction
ENSMUSG00000029283	Cdc7 / Q9Z0H0 / Cell division cycle 7-related protein kinase / O00311* / cell division cycle 7*	/ complex / reaction
ENSMUSG00000028452	Vcp / Q01853 / valosin containing protein / P55072*	/ complex / reaction
ENSMUSG00000031928	Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*	/ complex / reaction
ENSMUSG00000032596	Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*	/ reaction
ENSMUSG00000037991	Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*	/ complex / reaction
ENSMUSG00000041238	Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*	/ complex / reaction
ENSMUSG00000015120	Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*	/ reaction
ENSMUSG00000034329	Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*	/ complex / reaction
ENSMUSG00000025646	Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*	/ complex / reaction
ENSMUSG00000035960	Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*	/ complex / reaction
ENSMUSG00000030528	Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*	/ complex / reaction
ENSMUSG00000017499	Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*	/ complex / reaction
ENSMUSG00000036875	Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*	/ complex / reaction
ENSMUSG00000035692	Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*	/ reaction / complex
ENSMUSG00000022556	Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*	/ complex / reaction
ENSMUSG00000028884	Rpa2 / replication protein A2 / P15927*	/ complex
ENSMUSG00000056394	Lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*	/ complex / reaction
ENSMUSG00000027078	Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*	/ complex / reaction
ENSMUSG00000024926	Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*	/ complex / reaction
ENSMUSG00000034218	Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*	/ complex / reaction
ENSMUSG00000006678	Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*	/ complex / reaction
ENSMUSG00000020390	Ube2b / P63147 / ubiquitin-conjugating enzyme E2B / P63146*	/ complex / reaction
ENSMUSG00000031446	Cul4a / Q3TCH7 / Cullin-4A / Q13619*	/ complex / reaction
ENSMUSG00000020413	Hus1 / Q8BQY8 / Checkpoint protein HUS1 / O60921* / HUS1 checkpoint clamp component*	/ complex / reaction
ENSMUSG00000031095	Cul4b / A2A432 / Cullin-4B / Q13620*	/ complex / reaction
ENSMUSG00000012483	Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*	/ complex
ENSMUSG00000023953	Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*	/ complex / reaction
ENSMUSG00000024824	Rad9a / Q9Z0F6 / Cell cycle checkpoint control protein RAD9A / Q99638* / RAD9 checkpoint clamp component A*	/ complex / reaction
ENSMUSG00000024740	Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*	/ complex / reaction
ENSMUSG00000026134	Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*	/ complex / reaction
ENSMUSG00000024742	Fen1 / flap structure-specific endonuclease 1 / P39748*	/ complex / reaction
ENSMUSG00000022400	Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*	/ complex / reaction
ENSMUSG00000022248	Rad1 / Q9QWZ1 / Cell cycle checkpoint protein RAD1 / O60671* / RAD1 checkpoint DNA exonuclease*	/ complex / reaction
ENSMUSG00000024833	Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*	/ complex / reaction
ENSMUSG00000025395	Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*	/ complex / reaction
ENSMUSG00000024854	Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*	/ complex / reaction
ENSMUSG00000026429	Ube2t / Q9CQ37 / ubiquitin-conjugating enzyme E2T / Q9NPD8*	/ complex / reaction
ENSMUSG00000037474	Dtl / Q3TLR7 / Denticleless protein homolog / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*	/ complex / reaction
ENSMUSG00000038425	Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*	/ complex / reaction
ENSMUSG00000030697	Ppp4c / P97470 / protein phosphatase 4, catalytic subunit / P60510*	/ reaction
ENSMUSG00000028560	Usp1 / Q8BJQ2 / ubiquitin specific peptidase 1 / O94782*	/ complex / reaction
ENSMUSG00000039187	Fanci / Q8K368 / Fanconi anemia group I protein homolog / Q9NVI1* / Fanconi anemia complementation group I*	/ complex / reaction
ENSMUSG00000034023	Fancd2 / Q80V62 / Fanconi anemia group D2 protein homolog / Q9BXW9* / Fanconi anemia complementation group D2*	/ complex / reaction
ENSMUSG00000027342	Pcna / P17918 / proliferating cell nuclear antigen / P12004*	/ complex / reaction
ENSMUSG00000032512	Wdr48 / Q8BH57 / WD repeat domain 48 / Q8TAF3*	/ complex / reaction
ENSMUSG00000030254	Rad18 / Q9QXK2 / RAD18 E3 ubiquitin protein ligase / Q9NS91*	/ complex / reaction
ENSMUSG00000038569	Rad9b / Q6WBX7 / RAD9 checkpoint clamp component B / Q6WBX8*	/ complex / reaction
ENSMUSG00000038644	Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*	/ complex / reaction
ENSMUSG00000052144	Ppp4r2 / protein phosphatase 4 regulatory subunit 2 / Q9NY27*	/ reaction
ENSMUSG00000020471	Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr