ENSMUSG00000020114


Mus musculus
proteincomplexCand1regulationbindingassemblyubiquitinligasearmadillo-likehelicaltata-bindinginteractingtiparmadillo-typefoldscfubiquitinationcelldifferentiationcatalyticactivitytranscriptiondna-templatedrnapolymeraseiitranscriptionalpreinitiationnucleusnucleoplasmcytoplasm

Features
Gene ID: ENSMUSG00000020114
  
Biological name :Cand1
  
Synonyms : Cand1 / Cullin-associated NEDD8-dissociated protein 1 / Q6ZQ38
  
Possible biological names infered from orthology : cullin associated and neddylation dissociated 1 / Q86VP6
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 119199255
Gene end: 119240055
  
Corresponding Affymetrix probe sets: 10372750 (MoGene1.0st)   1428648_at (Mouse Genome 430 2.0 Array)   1428649_at (Mouse Genome 430 2.0 Array)   1435781_at (Mouse Genome 430 2.0 Array)   1455751_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115234
Ensembl peptide - ENSMUSP00000020315
NCBI entrez gene - 71902     See in Manteia.
MGI - MGI:1261820
RefSeq - NM_027994
RefSeq Peptide - NP_082270
swissprot - D3YWC5
swissprot - Q6ZQ38
Ensembl - ENSMUSG00000020114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cand1ENSDARG00000017841Danio rerio
 ENSGALG00000033879Gallus gallus
 ENSGALG00000009899Gallus gallus
 CAND1ENSG00000111530Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cand2 / Q6ZQ73 / Cullin-associated NEDD8-dissociated protein 2 / O75155* / cullin associated and neddylation dissociated 2 (putative)*ENSMUSG0000003031961


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR013932  TATA-binding protein interacting (TIP20)
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
cellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular component organizationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processregulation of molecular functionbiosynthetic processcellular componcellular component organizationcellular componcellular component biogenesisnitrogen compounitrogen compound metabolic processcellular metabocellular metabolic processprimary metabolprimary metabolic processorganic substanorganic substance metabolic processcellular develocellular developmental processregulation of mregulation of molecular functionbiosynthetic prbiosynthetic process
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellcellprotein-containing complexprotein-containing complexorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0010265 SCF complex assembly IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017025 TBP-class protein binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Neddylation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / complex / reaction
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000031143 Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000051355 Commd1 / Q8K4M5 / COMM domain-containing protein 1 / Q8N668* / copper metabolism domain containing 1*  / reaction
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex / reaction






 

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