ENSMUSG00000010376


Mus musculus

Features
Gene ID: ENSMUSG00000010376
  
Biological name :Nedd8
  
Synonyms : Nedd8 / P29595
  
Possible biological names infered from orthology : neural precursor cell expressed, developmentally down-regulated 8 / Q15843
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 55662263
Gene end: 55672124
  
Corresponding Affymetrix probe sets: 10420089 (MoGene1.0st)   1423715_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010520
Ensembl peptide - ENSMUSP00000130492
Ensembl peptide - ENSMUSP00000154561
NCBI entrez gene - 18002     See in Manteia.
MGI - MGI:97301
RefSeq - NM_008683
RefSeq Peptide - NP_032709
swissprot - P29595
swissprot - Q3UI46
Ensembl - ENSMUSG00000010376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nedd8ENSDARG00000007989Danio rerio
 nedd8lENSDARG00000103472Danio rerio
 NEDD8ENSG00000129559Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR019954  Ubiquitin conserved site
 IPR019956  Ubiquitin
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0008104 protein localization IDA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0045116 protein neddylation ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling activates SMADs
UCH proteinases
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022111 Uchl3 / Q9JKB1 / ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) / P15374* / ubiquitin C-terminal hydrolase L3*  / complex
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / complex / reaction
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex / reaction
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / complex / reaction
 ENSMUSG00000031143 Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*  / complex
 ENSMUSG00000031878 Nae1 / Q8VBW6 / NEDD8-activating enzyme E1 regulatory subunit / Q13564* / NEDD8 activating enzyme E1 subunit 1*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000035337 Uchl4 / P58321 / ubiquitin carboxyl-terminal esterase L4 / UCHL3* / P15374* / ubiquitin C-terminal hydrolase L3*  / complex
 ENSMUSG00000038545 Cul7 / Q8VE73 / Cullin-7 / Q14999*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000034343 Ube2f / Q9CY34 / ubiquitin-conjugating enzyme E2F (putative) / Q969M7*  / complex / reaction
 ENSMUSG00000051355 Commd1 / Q8K4M5 / COMM domain-containing protein 1 / Q8N668* / copper metabolism domain containing 1*  / complex
 ENSMUSG00000051705 Senp8 / Q9D2Z4 / Sentrin-specific protease 8 / Q96LD8* / SUMO/sentrin peptidase family member, NEDD8 specific*  / complex
 ENSMUSG00000040327 Cul9 / cullin 9 / Q8IWT3*  / complex / reaction
 ENSMUSG00000039753 Fbxl5 / Q8C2S5 / F-box/LRR-repeat protein 5 / Q9UKA1* / F-box and leucine rich repeat protein 5*  / complex / reaction
 ENSMUSG00000041117 Ccdc8 / D3YZV8 / Coiled-coil domain-containing / Q9H0W5* / coiled-coil domain containing 8*  / complex / reaction
 ENSMUSG00000030061 Uba3 / Q8C878 / ubiquitin-like modifier activating enzyme 3 / Q8TBC4*  / complex / reaction
 ENSMUSG00000026211 Obsl1 / D3YYU8 / Obscurin-like protein 1 / O75147* / obscurin like 1*  / complex / reaction
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / complex
 ENSMUSG00000025917 Cops5 / O35864 / COP9 signalosome complex subunit 5 / Q92905* / COP9 signalosome subunit 5*  / reaction
 ENSMUSG00000032030 Cul5 / cullin 5 / Q93034*  / complex
 ENSMUSG00000028954 Nub1 / P54729 / negative regulator of ubiquitin-like proteins 1 / Q9Y5A7*  / complex / reaction






 

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