ENSMUSG00000031878


Mus musculus

Features
Gene ID: ENSMUSG00000031878
  
Biological name :Nae1
  
Synonyms : Nae1 / NEDD8-activating enzyme E1 regulatory subunit / Q8VBW6
  
Possible biological names infered from orthology : NEDD8 activating enzyme E1 subunit 1 / Q13564
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 104511028
Gene end: 104534637
  
Corresponding Affymetrix probe sets: 10581111 (MoGene1.0st)   1423781_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034349
Ensembl peptide - ENSMUSP00000125456
NCBI entrez gene - 234664     See in Manteia.
MGI - MGI:2384561
RefSeq - XM_006530884
RefSeq - NM_144931
RefSeq Peptide - NP_659180
swissprot - Q3UK27
swissprot - Q8VBW6
swissprot - E0CZE0
Ensembl - ENSMUSG00000031878
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nae1ENSDARG00000011301Danio rerio
 NAE1ENSGALG00000038957Gallus gallus
 NAE1ENSG00000159593Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR030667  NEDD8-activating enzyme E1 regulatory subunit APP-BP1
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0033314 mitotic DNA replication checkpoint ISO
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0045116 protein neddylation ISO
 biological_processGO:0051402 neuron apoptotic process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0019781 NEDD8 activating enzyme activity IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0003201 extremity edema "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0010500 myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex / reaction
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / complex / reaction
 ENSMUSG00000030061 Uba3 / Q8C878 / ubiquitin-like modifier activating enzyme 3 / Q8TBC4*  / complex
 ENSMUSG00000034343 Ube2f / Q9CY34 / ubiquitin-conjugating enzyme E2F (putative) / Q969M7*  / complex / reaction






 

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