ENSMUSG00000024231


Mus musculus

Features
Gene ID: ENSMUSG00000024231
  
Biological name :Cul2
  
Synonyms : Cul2 / Cullin-2 / Q9D4H8
  
Possible biological names infered from orthology : Q13617
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 3382988
Gene end: 3436377
  
Corresponding Affymetrix probe sets: 10453575 (MoGene1.0st)   1419765_at (Mouse Genome 430 2.0 Array)   1451231_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025073
Ensembl peptide - ENSMUSP00000078988
Ensembl peptide - ENSMUSP00000123903
Ensembl peptide - ENSMUSP00000125403
NCBI entrez gene - 71745     See in Manteia.
MGI - MGI:1918995
RefSeq - XM_006526275
RefSeq - NM_029402
RefSeq - XM_006526274
RefSeq Peptide - NP_083678
swissprot - Q9D4H8
swissprot - H7BX52
swissprot - E0CYT5
Ensembl - ENSMUSG00000024231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul2ENSDARG00000013965Danio rerio
 CUL2ENSGALG00000007095Gallus gallus
 CUL2ENSG00000108094Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*ENSMUSG0000002968637
Cul4b / A2A432 / Cullin-4B / Q13620*ENSMUSG0000003109528
Cul5 / cullin 5 / Q93034*ENSMUSG0000003203028
Cul3 / Q9JLV5 / Cullin-3 / Q13618*ENSMUSG0000000436427
Cul4a / Q3TCH7 / Cullin-4A / Q13619*ENSMUSG0000003144627


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0030891 VCB complex IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / complex / reaction
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / complex / reaction
 ENSMUSG00000031987 Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*  / complex
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / complex / reaction
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / complex
 ENSMUSG00000035105 Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / complex
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000025239 Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*  / complex
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / reaction
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction






 

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