ENSG00000129559


Homo sapiens

Features
Gene ID: ENSG00000129559
  
Biological name :NEDD8
  
Synonyms : NEDD8 / neural precursor cell expressed, developmentally down-regulated 8 / Q15843
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q12
Gene start: 24216852
Gene end: 24232454
  
Corresponding Affymetrix probe sets: 201840_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380040
Ensembl peptide - ENSP00000448192
Ensembl peptide - ENSP00000250495
NCBI entrez gene - 4738     See in Manteia.
OMIM - 603171
RefSeq - NM_006156
RefSeq Peptide - NP_006147
swissprot - F8VSA6
swissprot - Q15843
Ensembl - ENSG00000129559
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nedd8ENSDARG00000007989Danio rerio
 nedd8lENSDARG00000103472Danio rerio
 Nedd8ENSMUSG00000010376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR019954  Ubiquitin conserved site
 IPR019956  Ubiquitin
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045116 protein neddylation IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling activates SMADs
UCH proteinases
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / complex / reaction
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex / reaction
 ENSG00000043093 Q96GG9 / DCUN1D1 / defective in cullin neddylation 1 domain containing 1  / complex / reaction
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / complex / reaction
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex / reaction
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / complex / reaction
 ENSG00000184182 UBE2F / Q969M7 / ubiquitin conjugating enzyme E2 F (putative)  / complex / reaction
 ENSG00000166192 SENP8 / Q96LD8 / SUMO/sentrin peptidase family member, NEDD8 specific  / complex
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / complex / reaction
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000144744 UBA3 / Q8TBC4 / ubiquitin like modifier activating enzyme 3  / complex / reaction
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / complex / reaction
 ENSG00000118939 UCHL3 / P15374 / ubiquitin C-terminal hydrolase L3  / complex
 ENSG00000112659 CUL9 / Q8IWT3 / cullin 9  / complex / reaction
 ENSG00000044090 CUL7 / Q14999 / cullin 7  / complex / reaction
 ENSG00000036257 CUL3 / Q13618 / cullin 3  / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction
 ENSG00000124006 OBSL1 / O75147 / obscurin like 1  / complex / reaction
 ENSG00000159593 NAE1 / Q13564 / NEDD8 activating enzyme E1 subunit 1  / complex / reaction
 ENSG00000169515 CCDC8 / Q9H0W5 / coiled-coil domain containing 8  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000118564 FBXL5 / Q9UKA1 / F-box and leucine rich repeat protein 5  / complex / reaction
 ENSG00000121022 COPS5 / Q92905 / COP9 signalosome subunit 5  / reaction
 ENSG00000108094 CUL2 / Q13617 / cullin 2  / complex
 ENSG00000166266 CUL5 / Q93034 / cullin 5  / complex
 ENSG00000013374 NUB1 / Q9Y5A7 / negative regulator of ubiquitin like proteins 1  / complex / reaction






 

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